Síntese de amidas e sulfonamidas de beta-D-galactopiranosilamina e beta-lactosilamina e avaliação de suas interações com lectinas de Erythrina cristagalli e de Ricinus communis Synthesis of amides and sulfonamides of beta-D- galactopyranosylamine and beta-lactosylamine and evaluation of their interactions with the lectins from Erythrina cristagalli and Ricinus communis

• Main Authors: Anna Paola Butera, José Dias de Souza Filho, Diogo Teixeira Carvalho, Rute Cunha Figueiredo, Luiz Carlos Alves de Faria, Maria Angélica Nunes, Maria Auxiliadora Fontes Prado, Ricardo José Alves, Milton Hércules Guerra de Andrade, Karina Taciana Santos Silva
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2007-10-01
• Series: Química Nova
• Subjects: carbohydrates; plant lectins; amides
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422007000500040
• ISSN: 0100-4042; 1678-7064

<abstract language="eng">We report herein the synthesis of some beta-D-galactopyranosylamine and beta-lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The beta-lactosylamine amides and sulfonamides were nearly as active as lactose in inhibiting LEC mediated hemagglutination and were less active against RCA120 agglutinin. The beta-D-galactopyranosylamine amides and sulfonamides were, with one exception, considerably less active than D-galactose in the assay with both lectins.