Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly
Weight loss, often observed in the elderly, is associated with increased risks of various diseases. No large and long-term human study has been conducted to demonstrate the health maintenance-related effects of lactic acid bacteria preparations. To reveal the potential benefit of long-term lactic ac...
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doaj-988ebf5cbb1a4e109c0bef70d4185e0d2020-11-25T02:48:59ZengMDPI AGNutrients2072-66432020-05-01121599159910.3390/nu12061599Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the ElderlyMichihiro Mutoh0Kenichi Yoshimura1Gen Fujii2Tomiyo Nakamura3Tatsuya Takeshita4Keiji Wakabayashi5Toshiyuki Sakai6Hideki Ishikawa7Department of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-0841, JapanCenter for Integrated Medical Research, Hiroshima University Hospital, Hiroshima 734-8551, JapanCentral Radioisotope Division, National Cancer Center Research Institute, Tokyo 104-0045, JapanDepartment of Food Sciences and Human Nutrition, Ryukoku University, Shiga 520-2194, JapanDepartment of Public Health, Wakayama Medical University School of Medicine, Wakayama 641-8509, JapanGraduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, JapanDepartment of Drug Discovery Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566, JapanDepartment of Molecular-Targeting Prevention, Kyoto Prefectural University of Medicine, Kyoto 602-0841, JapanWeight loss, often observed in the elderly, is associated with increased risks of various diseases. No large and long-term human study has been conducted to demonstrate the health maintenance-related effects of lactic acid bacteria preparations. To reveal the potential benefit of long-term lactic acid, the effects of bacteria-based probiotics for health maintenance were examined. This observational study included the participants from a previous clinical study designed to evaluate the effects of wheat bran biscuits or <i>Lactobacillus </i>preparation, 3 g/day biolactis powder (BLP), in preventing colorectal tumor. The participants were provided an option to continue treatment with BLP on an outpatient basis after completion of the study. The 380 patients who completed the study were contacted and asked to participate in the present study and those who consented were surveyed for cancer incidence, treatment compliance, lifestyle, weight, and other variables. Informed consent was obtained from 237 of the 380 (62.4%) patients. The mean follow-up period was 7913 days (21.7 years). Cancer developed in 24 of 128 (18.8%) patients in the BLP extension group and 24 of 109 (22.0%) patients in the non-BLP extension group (risk ratio 0.88 [95% confidence interval 0.53–1.47]). Although no significant difference was observed, the cumulative cancer incidence rose at a slightly lower rate in the BLP extension group. Both groups showed a significant weight decrease over the course of 20 years, although the decrease in the BLP extension group was only 1.4 kg, compared with 2.8 kg in the non-BLP extension group. Very long-term treatment with a <i>Lactobacillus</i> probiotic preparation suppressed weight loss in the elderly.https://www.mdpi.com/2072-6643/12/6/1599BLP<i>Lactobacillus</i>long-term treatmentweight loss |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michihiro Mutoh Kenichi Yoshimura Gen Fujii Tomiyo Nakamura Tatsuya Takeshita Keiji Wakabayashi Toshiyuki Sakai Hideki Ishikawa |
spellingShingle |
Michihiro Mutoh Kenichi Yoshimura Gen Fujii Tomiyo Nakamura Tatsuya Takeshita Keiji Wakabayashi Toshiyuki Sakai Hideki Ishikawa Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly Nutrients BLP <i>Lactobacillus</i> long-term treatment weight loss |
author_facet |
Michihiro Mutoh Kenichi Yoshimura Gen Fujii Tomiyo Nakamura Tatsuya Takeshita Keiji Wakabayashi Toshiyuki Sakai Hideki Ishikawa |
author_sort |
Michihiro Mutoh |
title |
Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly |
title_short |
Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly |
title_full |
Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly |
title_fullStr |
Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly |
title_full_unstemmed |
Very Long-Term Treatment with a <i>Lactobacillus</i> Probiotic Preparation, <i>Lactobacillus casei</i> Strain Shirota, Suppresses Weight Loss in the Elderly |
title_sort |
very long-term treatment with a <i>lactobacillus</i> probiotic preparation, <i>lactobacillus casei</i> strain shirota, suppresses weight loss in the elderly |
publisher |
MDPI AG |
series |
Nutrients |
issn |
2072-6643 |
publishDate |
2020-05-01 |
description |
Weight loss, often observed in the elderly, is associated with increased risks of various diseases. No large and long-term human study has been conducted to demonstrate the health maintenance-related effects of lactic acid bacteria preparations. To reveal the potential benefit of long-term lactic acid, the effects of bacteria-based probiotics for health maintenance were examined. This observational study included the participants from a previous clinical study designed to evaluate the effects of wheat bran biscuits or <i>Lactobacillus </i>preparation, 3 g/day biolactis powder (BLP), in preventing colorectal tumor. The participants were provided an option to continue treatment with BLP on an outpatient basis after completion of the study. The 380 patients who completed the study were contacted and asked to participate in the present study and those who consented were surveyed for cancer incidence, treatment compliance, lifestyle, weight, and other variables. Informed consent was obtained from 237 of the 380 (62.4%) patients. The mean follow-up period was 7913 days (21.7 years). Cancer developed in 24 of 128 (18.8%) patients in the BLP extension group and 24 of 109 (22.0%) patients in the non-BLP extension group (risk ratio 0.88 [95% confidence interval 0.53–1.47]). Although no significant difference was observed, the cumulative cancer incidence rose at a slightly lower rate in the BLP extension group. Both groups showed a significant weight decrease over the course of 20 years, although the decrease in the BLP extension group was only 1.4 kg, compared with 2.8 kg in the non-BLP extension group. Very long-term treatment with a <i>Lactobacillus</i> probiotic preparation suppressed weight loss in the elderly. |
topic |
BLP <i>Lactobacillus</i> long-term treatment weight loss |
url |
https://www.mdpi.com/2072-6643/12/6/1599 |
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