Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver
Background: Existing data show a correlation between the profile of fatty acids, liver, and blood. Therefore, the aim of our study was to investigate the correlation between the fatty acids profile in blood pallets and the liver. Methods: The experiment was performed on 60 eight-week-old male Spragu...
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doaj-9894f18846f749a3a5e3de5e940aa9e92020-11-24T21:55:19ZengMDPI AGDiagnostics2075-44182019-11-019419710.3390/diagnostics9040197diagnostics9040197Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the LiverDominika Maciejewska0Joanna Palma1Karolina Dec2Karolina Skonieczna-Żydecka3Izabela Gutowska4Małgorzata Szczuko5Karolina Jakubczyk6Ewa Stachowska7Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Medical Chemistry, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 70-204 Szczecin, PolandBackground: Existing data show a correlation between the profile of fatty acids, liver, and blood. Therefore, the aim of our study was to investigate the correlation between the fatty acids profile in blood pallets and the liver. Methods: The experiment was performed on 60 eight-week-old male Sprague-Dawley rats. The study group (<i>n</i> = 30, 5 groups, 6 rats each) received a cholesterol diet; the control group (<i>n</i> = 30, 5 groups, 6 rats each) received standard food for laboratory rats. The rats from both the study and control groups were sacrificed after 2, 4, 8, 12, and 16 weeks of dietary exposure. The fatty acids profile was measured using gas chromatography (GC). Results: In both the control and study group, the highest correlations were observed in palmitoleic acid (RHO = 0.68), heptadecanoic acid (RHO = 0.65), vaccenic acid (RHO = 0.72), eicosapentaenoic acid (RHO = 0.68), docosapentaenoic acid (RHO = 0.77), and docosahexaenoic (RHO = 0.77). Among liver indexes, the highest correlations were desaturase-18 (0.61). Conclusions: Fatty acids profile is a sensitive marker of the development of potentially pathological changes in the liver. The potential markers of fatty liver are: oleic acid, vaccenic acid, EPA, DHA, docosapentaenoic acid, and desaturase index (SCD-18 index).https://www.mdpi.com/2075-4418/9/4/197fatty acidnafldnashlipid markernon-invasive marker of nafld |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dominika Maciejewska Joanna Palma Karolina Dec Karolina Skonieczna-Żydecka Izabela Gutowska Małgorzata Szczuko Karolina Jakubczyk Ewa Stachowska |
spellingShingle |
Dominika Maciejewska Joanna Palma Karolina Dec Karolina Skonieczna-Żydecka Izabela Gutowska Małgorzata Szczuko Karolina Jakubczyk Ewa Stachowska Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver Diagnostics fatty acid nafld nash lipid marker non-invasive marker of nafld |
author_facet |
Dominika Maciejewska Joanna Palma Karolina Dec Karolina Skonieczna-Żydecka Izabela Gutowska Małgorzata Szczuko Karolina Jakubczyk Ewa Stachowska |
author_sort |
Dominika Maciejewska |
title |
Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver |
title_short |
Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver |
title_full |
Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver |
title_fullStr |
Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver |
title_full_unstemmed |
Is the Fatty Acids Profile in Blood a Good Predictor of Liver Changes? Correlation of Fatty Acids Profile with Fatty Acids Content in the Liver |
title_sort |
is the fatty acids profile in blood a good predictor of liver changes? correlation of fatty acids profile with fatty acids content in the liver |
publisher |
MDPI AG |
series |
Diagnostics |
issn |
2075-4418 |
publishDate |
2019-11-01 |
description |
Background: Existing data show a correlation between the profile of fatty acids, liver, and blood. Therefore, the aim of our study was to investigate the correlation between the fatty acids profile in blood pallets and the liver. Methods: The experiment was performed on 60 eight-week-old male Sprague-Dawley rats. The study group (<i>n</i> = 30, 5 groups, 6 rats each) received a cholesterol diet; the control group (<i>n</i> = 30, 5 groups, 6 rats each) received standard food for laboratory rats. The rats from both the study and control groups were sacrificed after 2, 4, 8, 12, and 16 weeks of dietary exposure. The fatty acids profile was measured using gas chromatography (GC). Results: In both the control and study group, the highest correlations were observed in palmitoleic acid (RHO = 0.68), heptadecanoic acid (RHO = 0.65), vaccenic acid (RHO = 0.72), eicosapentaenoic acid (RHO = 0.68), docosapentaenoic acid (RHO = 0.77), and docosahexaenoic (RHO = 0.77). Among liver indexes, the highest correlations were desaturase-18 (0.61). Conclusions: Fatty acids profile is a sensitive marker of the development of potentially pathological changes in the liver. The potential markers of fatty liver are: oleic acid, vaccenic acid, EPA, DHA, docosapentaenoic acid, and desaturase index (SCD-18 index). |
topic |
fatty acid nafld nash lipid marker non-invasive marker of nafld |
url |
https://www.mdpi.com/2075-4418/9/4/197 |
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