Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System
Gene expression noise is not just ubiquitous but also variable, and we still do not understand some of the most elementary factors that affect it. Among them is the residence time of a transcription factor (TF) on DNA, the mean time that a DNA-bound TF remains bound. Here, we use a stochastic model...
Main Authors: | , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-04-01
|
Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmolb.2020.00067/full |
id |
doaj-98a79fb270854d7698545b430c73c670 |
---|---|
record_format |
Article |
spelling |
doaj-98a79fb270854d7698545b430c73c6702020-11-25T02:54:24ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2020-04-01710.3389/fmolb.2020.00067521344Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation SystemEugenio Azpeitia0Eugenio Azpeitia1Eugenio Azpeitia2Andreas Wagner3Andreas Wagner4Andreas Wagner5Department of Evolutionary Biology and Environmental Studies, University of Zürich, Zurich, SwitzerlandSwiss Institute of Bioinformatics, Lausanne, SwitzerlandCentro de Ciencias Matemáticas, UNAM, Morelia, MexicoDepartment of Evolutionary Biology and Environmental Studies, University of Zürich, Zurich, SwitzerlandSwiss Institute of Bioinformatics, Lausanne, SwitzerlandSanta Fe Institute, Santa Fe, NM, United StatesGene expression noise is not just ubiquitous but also variable, and we still do not understand some of the most elementary factors that affect it. Among them is the residence time of a transcription factor (TF) on DNA, the mean time that a DNA-bound TF remains bound. Here, we use a stochastic model of transcriptional regulation to study how residence time affects the gene expression noise that arises when a TF induces gene expression. We find that the effect of residence time on gene expression noise depends on the TF’s concentration and its affinity to DNA, which determine the level of induction of the gene. At high levels of induction, residence time has no effect on gene expression noise. However, as the level of induction decreases, short residence times reduce gene expression noise. The reason is that fast on-off TF binding dynamics prevent long periods where proteins are predominantly synthesized or degraded, which can cause excessive fluctuations in gene expression. As a consequence, short residence times can help a gene regulation system acquire information about the cellular environment it operates in. Our predictions are consistent with the observation that experimentally measured residence times are usually modest and lie between seconds to minutes.https://www.frontiersin.org/article/10.3389/fmolb.2020.00067/fullresidence timetranscription factor-DNA interactionregulation of gene expressiongene expression noiseInformation acquisitionstochastic processes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Eugenio Azpeitia Eugenio Azpeitia Eugenio Azpeitia Andreas Wagner Andreas Wagner Andreas Wagner |
spellingShingle |
Eugenio Azpeitia Eugenio Azpeitia Eugenio Azpeitia Andreas Wagner Andreas Wagner Andreas Wagner Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System Frontiers in Molecular Biosciences residence time transcription factor-DNA interaction regulation of gene expression gene expression noise Information acquisition stochastic processes |
author_facet |
Eugenio Azpeitia Eugenio Azpeitia Eugenio Azpeitia Andreas Wagner Andreas Wagner Andreas Wagner |
author_sort |
Eugenio Azpeitia |
title |
Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System |
title_short |
Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System |
title_full |
Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System |
title_fullStr |
Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System |
title_full_unstemmed |
Short Residence Times of DNA-Bound Transcription Factors Can Reduce Gene Expression Noise and Increase the Transmission of Information in a Gene Regulation System |
title_sort |
short residence times of dna-bound transcription factors can reduce gene expression noise and increase the transmission of information in a gene regulation system |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Molecular Biosciences |
issn |
2296-889X |
publishDate |
2020-04-01 |
description |
Gene expression noise is not just ubiquitous but also variable, and we still do not understand some of the most elementary factors that affect it. Among them is the residence time of a transcription factor (TF) on DNA, the mean time that a DNA-bound TF remains bound. Here, we use a stochastic model of transcriptional regulation to study how residence time affects the gene expression noise that arises when a TF induces gene expression. We find that the effect of residence time on gene expression noise depends on the TF’s concentration and its affinity to DNA, which determine the level of induction of the gene. At high levels of induction, residence time has no effect on gene expression noise. However, as the level of induction decreases, short residence times reduce gene expression noise. The reason is that fast on-off TF binding dynamics prevent long periods where proteins are predominantly synthesized or degraded, which can cause excessive fluctuations in gene expression. As a consequence, short residence times can help a gene regulation system acquire information about the cellular environment it operates in. Our predictions are consistent with the observation that experimentally measured residence times are usually modest and lie between seconds to minutes. |
topic |
residence time transcription factor-DNA interaction regulation of gene expression gene expression noise Information acquisition stochastic processes |
url |
https://www.frontiersin.org/article/10.3389/fmolb.2020.00067/full |
work_keys_str_mv |
AT eugenioazpeitia shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem AT eugenioazpeitia shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem AT eugenioazpeitia shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem AT andreaswagner shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem AT andreaswagner shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem AT andreaswagner shortresidencetimesofdnaboundtranscriptionfactorscanreducegeneexpressionnoiseandincreasethetransmissionofinformationinageneregulationsystem |
_version_ |
1724721427129565184 |