Refractory cardiopulmonary failure after glyphosate surfactant intoxication: a case report

<p>Abstract</p> <p>Background</p> <p>Glyphosate is an herbicide considered to be of low toxicity to humans because its effects are specific to plants. However, fatal reactions to glyphosate have been reported after the ingestion of large amounts. Pulmonary edema, shock,...

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Bibliographic Details
Main Authors: Chang Chia-Chu, Chang Chirn-Bin
Format: Article
Language:English
Published: BMC 2009-01-01
Series:Journal of Occupational Medicine and Toxicology
Online Access:http://www.occup-med.com/content/4/1/2
Description
Summary:<p>Abstract</p> <p>Background</p> <p>Glyphosate is an herbicide considered to be of low toxicity to humans because its effects are specific to plants. However, fatal reactions to glyphosate have been reported after the ingestion of large amounts. Pulmonary edema, shock, and arrhythmia were the reported causes of mortality.</p> <p>Case presentation</p> <p>We present the case of a 57-year-old woman who was admitted to the emergency department unconsciousness after ingestion of glyphosate surfactant in a suicide attempt. Metabolic acidosis, refractory respiratory failure, and shock developed during hospitalization. Despite aggressive supportive care, the patient died in the hospital.</p> <p>Conclusion</p> <p>The toxicokinetics of glyphosate surfactant is complicated. Respiratory failure, metabolic acidosis, tachycardia, elevated creatinine, and hyperkalemia are poor prognostic factors if presented. Physicians should consider using hemodialysis early to improve the outcome of patients with glyphosate surfactant intoxication.</p>
ISSN:1745-6673