tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan...
Main Authors: | , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2020-01-01
|
Series: | Oxidative Medicine and Cellular Longevity |
Online Access: | http://dx.doi.org/10.1155/2020/3123268 |
id |
doaj-98c825ae5be04b87b84625ea4a11f72b |
---|---|
record_format |
Article |
spelling |
doaj-98c825ae5be04b87b84625ea4a11f72b2020-11-25T02:33:30ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942020-01-01202010.1155/2020/31232683123268tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of PalmitatePedro Posadas-Rodríguez0Natalia Esmeralda Posadas-Rodríguez1Viridiana Yazmín González-Puertos2Rafael Toledo-Pérez3José Luis Ventura-Gallegos4Alejandro Zentella5Luis Enrique Gómez-Quiroz6Mina Königsberg7Armando Luna-López8Departamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento Medicina Genómica y Toxicología Ambiental, IIB, UNAM, México, DF, MexicoDepartamento Medicina Genómica y Toxicología Ambiental, IIB, UNAM, México, DF, MexicoDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento de Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de México, MexicoDepartamento de Investigación Básica, Instituto Nacional de Geriatría, SSA, Ciudad de México, MexicoNutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB.http://dx.doi.org/10.1155/2020/3123268 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pedro Posadas-Rodríguez Natalia Esmeralda Posadas-Rodríguez Viridiana Yazmín González-Puertos Rafael Toledo-Pérez José Luis Ventura-Gallegos Alejandro Zentella Luis Enrique Gómez-Quiroz Mina Königsberg Armando Luna-López |
spellingShingle |
Pedro Posadas-Rodríguez Natalia Esmeralda Posadas-Rodríguez Viridiana Yazmín González-Puertos Rafael Toledo-Pérez José Luis Ventura-Gallegos Alejandro Zentella Luis Enrique Gómez-Quiroz Mina Königsberg Armando Luna-López tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate Oxidative Medicine and Cellular Longevity |
author_facet |
Pedro Posadas-Rodríguez Natalia Esmeralda Posadas-Rodríguez Viridiana Yazmín González-Puertos Rafael Toledo-Pérez José Luis Ventura-Gallegos Alejandro Zentella Luis Enrique Gómez-Quiroz Mina Königsberg Armando Luna-López |
author_sort |
Pedro Posadas-Rodríguez |
title |
tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_short |
tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_full |
tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_fullStr |
tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_full_unstemmed |
tBHQ Induces a Hormetic Response That Protects L6 Myoblasts against the Toxic Effect of Palmitate |
title_sort |
tbhq induces a hormetic response that protects l6 myoblasts against the toxic effect of palmitate |
publisher |
Hindawi Limited |
series |
Oxidative Medicine and Cellular Longevity |
issn |
1942-0900 1942-0994 |
publishDate |
2020-01-01 |
description |
Nutritional status, in particular overweight and obesity, as well as sedentarism and high-fat diet consumption, are important risk factors to develop chronic diseases, which have a higher impact on the elderly’s health. Therefore, these nutritional problems have become a concern to human healthspan and longevity. The fatty acids obtained thru the diet or due to fatty acid synthesis during obesity accumulate within the body generating toxicity and cell death. Fat is not only stored in adipose tissue, but it can also be stored in skeletal muscle. Palmitic acid (PA) has been reported as one of the most important saturated free fatty acids; it is associated to chronic oxidative stress and increased mitochondrial ROS production causing cell death by apoptosis. In skeletal muscle, palmitate has been associated with various pathophysiological consequences, which lead to muscle deterioration during aging and obesity. Since molecules that modify redox state have been proven to prevent cellular damage by inducing a hormetic response, the aim of this study was to evaluate if tert-butylhydroquinone (tBHQ) could activate an antioxidant hormetic response that would be able to protect L6 myoblasts from palmitate toxic effect. Our results provide evidence that tBHQ is able to protect L6 myoblasts against the toxicity induced by sodium palmitate due to a synergistic activation of different signaling pathways such as Nrf2 and NF-κB. |
url |
http://dx.doi.org/10.1155/2020/3123268 |
work_keys_str_mv |
AT pedroposadasrodriguez tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT nataliaesmeraldaposadasrodriguez tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT viridianayazmingonzalezpuertos tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT rafaeltoledoperez tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT joseluisventuragallegos tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT alejandrozentella tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT luisenriquegomezquiroz tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT minakonigsberg tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate AT armandolunalopez tbhqinducesahormeticresponsethatprotectsl6myoblastsagainstthetoxiceffectofpalmitate |
_version_ |
1715451794237161472 |