The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity
Abstract In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and...
Main Authors: | Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo, Fabrizio Barbetti, Roberto Contestabile, Fiammetta Vernì |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-10-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-019-50673-4 |
Similar Items
-
Functional Inactivation of <i>Drosophila</i> <i>GCK</i> Orthologs Causes Genomic Instability and Oxidative Stress in a Fly Model of MODY-2
by: Elisa Mascolo, et al.
Published: (2021-01-01) -
The Relationship Between Vitamin B6, Diabetes and Cancer
by: Chiara Merigliano, et al.
Published: (2018-09-01) -
The multifaceted role of vitamin B6 in cancer: Drosophila as a model system to investigate DNA damage
by: Roberto Contestabile, et al.
Published: (2020-03-01) -
Pyridoxal 5'-phosphate is a slow tight binding inhibitor of E. coli pyridoxal kinase.
by: Mohini S Ghatge, et al.
Published: (2012-01-01) -
Crystal structures of human pyridoxal kinase in complex with the neurotoxins, ginkgotoxin and theophylline: insights into pyridoxal kinase inhibition.
by: Amit K Gandhi, et al.
Published: (2012-01-01)