Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
Molecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue rec...
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2017-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-017-00953-2 |
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doaj-98cda6910c484a9693175095f267419e2021-05-11T07:35:39ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-00953-2Blood vessel control of macrophage maturation promotes arteriogenesis in ischemiaKashyap Krishnasamy0Anne Limbourg1Tamar Kapanadze2Jaba Gamrekelashvili3Christian Beger4Christine Häger5Vladimir J. Lozanovski6Christine S. Falk7L. Christian Napp8Johann Bauersachs9Matthias Mack10Hermann Haller11Christian Weber12Ralf H. Adams13Florian P. Limbourg14Vascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolIntegrated Research and Treatment Center Transplantation, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolDepartment of Cardiology, Hannover Medical SchoolDepartment of Nephrology, UniklinikumDepartment of Nephrology and Hypertension, Hannover Medical SchoolInstitute for Cardiovascular Prevention, and German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Ludwig-Maximilians-UniversityDepartment of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine, and University of MünsterVascular Medicine Research, Hannover Medical SchoolMolecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue recovery.https://doi.org/10.1038/s41467-017-00953-2 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kashyap Krishnasamy Anne Limbourg Tamar Kapanadze Jaba Gamrekelashvili Christian Beger Christine Häger Vladimir J. Lozanovski Christine S. Falk L. Christian Napp Johann Bauersachs Matthias Mack Hermann Haller Christian Weber Ralf H. Adams Florian P. Limbourg |
spellingShingle |
Kashyap Krishnasamy Anne Limbourg Tamar Kapanadze Jaba Gamrekelashvili Christian Beger Christine Häger Vladimir J. Lozanovski Christine S. Falk L. Christian Napp Johann Bauersachs Matthias Mack Hermann Haller Christian Weber Ralf H. Adams Florian P. Limbourg Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia Nature Communications |
author_facet |
Kashyap Krishnasamy Anne Limbourg Tamar Kapanadze Jaba Gamrekelashvili Christian Beger Christine Häger Vladimir J. Lozanovski Christine S. Falk L. Christian Napp Johann Bauersachs Matthias Mack Hermann Haller Christian Weber Ralf H. Adams Florian P. Limbourg |
author_sort |
Kashyap Krishnasamy |
title |
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
title_short |
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
title_full |
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
title_fullStr |
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
title_full_unstemmed |
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
title_sort |
blood vessel control of macrophage maturation promotes arteriogenesis in ischemia |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2017-10-01 |
description |
Molecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue recovery. |
url |
https://doi.org/10.1038/s41467-017-00953-2 |
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