Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia

Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia

Molecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue rec...

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Main Authors: Kashyap Krishnasamy, Anne Limbourg, Tamar Kapanadze, Jaba Gamrekelashvili, Christian Beger, Christine Häger, Vladimir J. Lozanovski, Christine S. Falk, L. Christian Napp, Johann Bauersachs, Matthias Mack, Hermann Haller, Christian Weber, Ralf H. Adams, Florian P. Limbourg
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00953-2
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spelling doaj-98cda6910c484a9693175095f267419e2021-05-11T07:35:39ZengNature Publishing GroupNature Communications2041-17232017-10-018111410.1038/s41467-017-00953-2Blood vessel control of macrophage maturation promotes arteriogenesis in ischemiaKashyap Krishnasamy0Anne Limbourg1Tamar Kapanadze2Jaba Gamrekelashvili3Christian Beger4Christine Häger5Vladimir J. Lozanovski6Christine S. Falk7L. Christian Napp8Johann Bauersachs9Matthias Mack10Hermann Haller11Christian Weber12Ralf H. Adams13Florian P. Limbourg14Vascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolIntegrated Research and Treatment Center Transplantation, Hannover Medical SchoolVascular Medicine Research, Hannover Medical SchoolDepartment of Cardiology, Hannover Medical SchoolDepartment of Nephrology, UniklinikumDepartment of Nephrology and Hypertension, Hannover Medical SchoolInstitute for Cardiovascular Prevention, and German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Ludwig-Maximilians-UniversityDepartment of Tissue Morphogenesis, Faculty of Medicine, Max-Planck-Institute for Molecular Biomedicine, and University of MünsterVascular Medicine Research, Hannover Medical SchoolMolecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue recovery.https://doi.org/10.1038/s41467-017-00953-2
collection DOAJ
language English
format Article
sources DOAJ
author Kashyap Krishnasamy
Anne Limbourg
Tamar Kapanadze
Jaba Gamrekelashvili
Christian Beger
Christine Häger
Vladimir J. Lozanovski
Christine S. Falk
L. Christian Napp
Johann Bauersachs
Matthias Mack
Hermann Haller
Christian Weber
Ralf H. Adams
Florian P. Limbourg
spellingShingle Kashyap Krishnasamy
Anne Limbourg
Tamar Kapanadze
Jaba Gamrekelashvili
Christian Beger
Christine Häger
Vladimir J. Lozanovski
Christine S. Falk
L. Christian Napp
Johann Bauersachs
Matthias Mack
Hermann Haller
Christian Weber
Ralf H. Adams
Florian P. Limbourg
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
Nature Communications
author_facet Kashyap Krishnasamy
Anne Limbourg
Tamar Kapanadze
Jaba Gamrekelashvili
Christian Beger
Christine Häger
Vladimir J. Lozanovski
Christine S. Falk
L. Christian Napp
Johann Bauersachs
Matthias Mack
Hermann Haller
Christian Weber
Ralf H. Adams
Florian P. Limbourg
author_sort Kashyap Krishnasamy
title Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
title_short Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
title_full Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
title_fullStr Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
title_full_unstemmed Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
title_sort blood vessel control of macrophage maturation promotes arteriogenesis in ischemia
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description Molecular mechanisms of macrophage-mediated regulation of artery growth in response to ischemia are poorly understood. Here the authors show that vascular endothelium controls macrophage maturation and differentiation via Notch signaling, which in turn promotes arteriogenesis and ischemic tissue recovery.
url https://doi.org/10.1038/s41467-017-00953-2
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