Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome
Sezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hemato...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
PAGEPress Publications
2018-09-01
|
Series: | Hematology Reports |
Subjects: | |
Online Access: | https://www.pagepress.org/journals/index.php/hr/article/view/7497 |
id |
doaj-98dc4b71503b42cf8c6fe7cfd767166b |
---|---|
record_format |
Article |
spelling |
doaj-98dc4b71503b42cf8c6fe7cfd767166b2020-11-25T04:03:34ZengPAGEPress PublicationsHematology Reports2038-83222038-83302018-09-0110310.4081/hr.2018.74973992Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndromeHiroki Hosoi0Kazuo Hatanaka1Shogo Murata2Toshiki Mushino3Kodai Kuriyama4Akinori Nishikawa5Nobuyoshi Hanaoka6Shinobu Tamura7Hideki Nakakuma8Takashi Sonoki9Department of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaDepartment of Hematology/Oncology, Wakayama Medical University, WakayamaSezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hematological relapse within one month after transplantation. After discontinuation of immunosuppressants, she achieved complete remission and remained relapse-free. The chimeric analyses of Tcells showed that the full recipient type became complete donor chimera after immunological symptoms. This clinical course suggested that discontinuation of immunosuppressants may result in a graftversus- tumor effect, leading to the eradication of lymphoma cells.https://www.pagepress.org/journals/index.php/hr/article/view/7497Sezary syndromeAllo-HSCTGraft versus tumor effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hiroki Hosoi Kazuo Hatanaka Shogo Murata Toshiki Mushino Kodai Kuriyama Akinori Nishikawa Nobuyoshi Hanaoka Shinobu Tamura Hideki Nakakuma Takashi Sonoki |
spellingShingle |
Hiroki Hosoi Kazuo Hatanaka Shogo Murata Toshiki Mushino Kodai Kuriyama Akinori Nishikawa Nobuyoshi Hanaoka Shinobu Tamura Hideki Nakakuma Takashi Sonoki Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome Hematology Reports Sezary syndrome Allo-HSCT Graft versus tumor effect |
author_facet |
Hiroki Hosoi Kazuo Hatanaka Shogo Murata Toshiki Mushino Kodai Kuriyama Akinori Nishikawa Nobuyoshi Hanaoka Shinobu Tamura Hideki Nakakuma Takashi Sonoki |
author_sort |
Hiroki Hosoi |
title |
Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome |
title_short |
Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome |
title_full |
Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome |
title_fullStr |
Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome |
title_full_unstemmed |
Long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for Sezary syndrome |
title_sort |
long-term complete remission of early hematological relapse after discontinuation of immunosuppressants following allogeneic transplantation for sezary syndrome |
publisher |
PAGEPress Publications |
series |
Hematology Reports |
issn |
2038-8322 2038-8330 |
publishDate |
2018-09-01 |
description |
Sezary syndrome (SS) is a leukemic form of cutaneous T-cell lymphoma and is chemo-resistant. Allogeneic hematopoietic stem cell transplantation is a promising therapy for SS; however, relapse is common. Therapeutic options after relapse have not been established. We managed an SS patient with hematological relapse within one month after transplantation. After discontinuation of immunosuppressants, she achieved complete remission and remained relapse-free. The chimeric analyses of Tcells showed that the full recipient type became complete donor chimera after immunological symptoms. This clinical course suggested that discontinuation of immunosuppressants may result in a graftversus- tumor effect, leading to the eradication of lymphoma cells. |
topic |
Sezary syndrome Allo-HSCT Graft versus tumor effect |
url |
https://www.pagepress.org/journals/index.php/hr/article/view/7497 |
work_keys_str_mv |
AT hirokihosoi longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT kazuohatanaka longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT shogomurata longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT toshikimushino longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT kodaikuriyama longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT akinorinishikawa longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT nobuyoshihanaoka longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT shinobutamura longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT hidekinakakuma longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome AT takashisonoki longtermcompleteremissionofearlyhematologicalrelapseafterdiscontinuationofimmunosuppressantsfollowingallogeneictransplantationforsezarysyndrome |
_version_ |
1724439574118137856 |