Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures
Protamines confer a compact structure to the genome of male gametes. Here, we find that somatic cells can be remodeled by transient expression of protamine 1 (Prm1). Ectopically expressed Prm1 forms scattered foci in the nuclei of fibroblasts, which coalescence into spermatid-like structures, concom...
Main Authors: | Domenico Iuso, Marta Czernik, Paola Toschi, Antonella Fidanza, Federica Zacchini, Robert Feil, Sandrine Curtet, Thierry Buchou, Hitoshi Shiota, Saadi Khochbin, Grazyna Ewa Ptak, Pasqualino Loi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2015-12-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715012553 |
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