Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5.
Intracellular inclusions of aggregated tau appear in neurons and glial cells in a range of neurodegenerative diseases known as tauopathies. Inhibition of pathological changes in tau is a therapeutic target for tauopathy. We recently synthesized a novel curcumin derivative, named Shiga-Y5, and showed...
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doaj-98de34af1de442fdaa9a3ba6c0e311d52021-03-03T21:03:54ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-011312e020844010.1371/journal.pone.0208440Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5.Daijiro YanagisawaHamizah Shahirah HamezahLina Wati DuraniHiroyasu TaguchiIkuo TooyamaIntracellular inclusions of aggregated tau appear in neurons and glial cells in a range of neurodegenerative diseases known as tauopathies. Inhibition of pathological changes in tau is a therapeutic target for tauopathy. We recently synthesized a novel curcumin derivative, named Shiga-Y5, and showed that Shiga-Y5 inhibited cognitive impairment and amyloid deposition in a mouse model of Alzheimer's disease. Here we investigated whether Shiga-Y5 inhibited cognitive impairment and tau accumulation in a mouse model of tauopathy, rTg4510. The rTg4510 mouse is a bitransgenic mouse model that uses a system of responder and activator transgenes to express human four-repeat tau with the P301L mutation. This strain is obtained by crossing tetO-MAPT*P301L mouse line (on a FVB/NJ background) with CaMKII-tTA mouse line (on a C57BL/6J background). Male rTg4510 mice and wild-type mice were fed with a standard chow diet with or without Shiga-Y5 (500 ppm) for 4 months. Behavioral tests were conducted from 5.5 months of age, and the mice were sacrificed at 6 months of age. There were no significant changes in behavioral performance in rTg4510 mice fed with SY5-containing chow diet compared with rTg4510 mice fed with control chow diet. Histological and biochemical analyses also showed no significant alterations in tau accumulation by the treatment with SY5. One of noticeable finding in this study was that rTg4510 mice on a F1 female FVB/NJ x male C57BL/6J background showed more severe tau accumulation than rTg4510 mice on a F1 female C57BL/6J x male FVB/NJ background. Further studies to clarify the mechanisms underlying tau aggregation may help to develop therapeutic approaches aimed at preventing this pathological feature.https://doi.org/10.1371/journal.pone.0208440 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Daijiro Yanagisawa Hamizah Shahirah Hamezah Lina Wati Durani Hiroyasu Taguchi Ikuo Tooyama |
spellingShingle |
Daijiro Yanagisawa Hamizah Shahirah Hamezah Lina Wati Durani Hiroyasu Taguchi Ikuo Tooyama Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. PLoS ONE |
author_facet |
Daijiro Yanagisawa Hamizah Shahirah Hamezah Lina Wati Durani Hiroyasu Taguchi Ikuo Tooyama |
author_sort |
Daijiro Yanagisawa |
title |
Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. |
title_short |
Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. |
title_full |
Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. |
title_fullStr |
Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. |
title_full_unstemmed |
Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. |
title_sort |
study of tau pathology in male rtg4510 mice fed with a curcumin derivative shiga-y5. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2018-01-01 |
description |
Intracellular inclusions of aggregated tau appear in neurons and glial cells in a range of neurodegenerative diseases known as tauopathies. Inhibition of pathological changes in tau is a therapeutic target for tauopathy. We recently synthesized a novel curcumin derivative, named Shiga-Y5, and showed that Shiga-Y5 inhibited cognitive impairment and amyloid deposition in a mouse model of Alzheimer's disease. Here we investigated whether Shiga-Y5 inhibited cognitive impairment and tau accumulation in a mouse model of tauopathy, rTg4510. The rTg4510 mouse is a bitransgenic mouse model that uses a system of responder and activator transgenes to express human four-repeat tau with the P301L mutation. This strain is obtained by crossing tetO-MAPT*P301L mouse line (on a FVB/NJ background) with CaMKII-tTA mouse line (on a C57BL/6J background). Male rTg4510 mice and wild-type mice were fed with a standard chow diet with or without Shiga-Y5 (500 ppm) for 4 months. Behavioral tests were conducted from 5.5 months of age, and the mice were sacrificed at 6 months of age. There were no significant changes in behavioral performance in rTg4510 mice fed with SY5-containing chow diet compared with rTg4510 mice fed with control chow diet. Histological and biochemical analyses also showed no significant alterations in tau accumulation by the treatment with SY5. One of noticeable finding in this study was that rTg4510 mice on a F1 female FVB/NJ x male C57BL/6J background showed more severe tau accumulation than rTg4510 mice on a F1 female C57BL/6J x male FVB/NJ background. Further studies to clarify the mechanisms underlying tau aggregation may help to develop therapeutic approaches aimed at preventing this pathological feature. |
url |
https://doi.org/10.1371/journal.pone.0208440 |
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