Altered gut microbiota and microbial biomarkers associated with chronic kidney disease
Abstract The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences i...
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doaj-98e083ca05b44d40ae24cb8dba472b0b2020-11-25T01:06:31ZengWileyMicrobiologyOpen2045-88272019-04-0184n/an/a10.1002/mbo3.678Altered gut microbiota and microbial biomarkers associated with chronic kidney diseaseHengzhong Lun0Weihua Yang1Shuping Zhao2Meijie Jiang3Mingjie Xu4Fenfen Liu5Yunshan Wang6Medical Research & Laboratory Diagnostic Center Jinan Central Hospital Affiliated to Shandong University Jinan Shandong ChinaMedical Research & Laboratory Diagnostic Center Jinan Central Hospital Affiliated to Shandong University Jinan Shandong ChinaThe Department of Clinical Laboratory Taian City Central Hospital Taian Shandong ChinaThe Department of Clinical Laboratory Taian City Central Hospital Taian Shandong ChinaMedical Research & Laboratory Diagnostic Center Jinan Central Hospital Affiliated to Shandong University Jinan Shandong ChinaThe Department of Nephrology Taian City Central Hospital Taian Shandong ChinaMedical Research & Laboratory Diagnostic Center Jinan Central Hospital Affiliated to Shandong University Jinan Shandong ChinaAbstract The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences in gut microbiota between the CKD and HC groups. The study found that 12 phylotypes were overrepresented in the CKD group and 19 in the HC group at the genus level. Furthermore, genera Lachnospira and Ruminococcus_gnavus performed the best in differentiating between HC and CKD populations. In addition, this novel study found that the genera Holdemanella, Megamonas, Prevotella 2, Dielma, and Scardovia were associated with the progression of CKD and hemodialysis. In conclusion, the composition of gut microbiota was different in CKD populations compared with healthy populations, and Lachnospira and R._gnavus were better microbial biomarkers. In addition, five phylotypes, including Holdemanella, Megamonas, Prevotella2, Dielma, and Scardovia, served as an indicator of the progression of CKD and hemodialysis. However, large‐scale prospective studies should be performed to identify the reliability of the set of these phylotypes as biomarkers.https://doi.org/10.1002/mbo3.678chronic kidney diseasegut microbiotahemodialysisintestinal dysbiosismicrobial biomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hengzhong Lun Weihua Yang Shuping Zhao Meijie Jiang Mingjie Xu Fenfen Liu Yunshan Wang |
spellingShingle |
Hengzhong Lun Weihua Yang Shuping Zhao Meijie Jiang Mingjie Xu Fenfen Liu Yunshan Wang Altered gut microbiota and microbial biomarkers associated with chronic kidney disease MicrobiologyOpen chronic kidney disease gut microbiota hemodialysis intestinal dysbiosis microbial biomarker |
author_facet |
Hengzhong Lun Weihua Yang Shuping Zhao Meijie Jiang Mingjie Xu Fenfen Liu Yunshan Wang |
author_sort |
Hengzhong Lun |
title |
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
title_short |
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
title_full |
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
title_fullStr |
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
title_full_unstemmed |
Altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
title_sort |
altered gut microbiota and microbial biomarkers associated with chronic kidney disease |
publisher |
Wiley |
series |
MicrobiologyOpen |
issn |
2045-8827 |
publishDate |
2019-04-01 |
description |
Abstract The present study aimed to determine the differences in gut microbiota between patients with chronic kidney disease (CKD) and healthy controls (HC) and search for better microbial biomarkers associated with CKD. The 16S rRNA gene sequencing approach was used to investigate the differences in gut microbiota between the CKD and HC groups. The study found that 12 phylotypes were overrepresented in the CKD group and 19 in the HC group at the genus level. Furthermore, genera Lachnospira and Ruminococcus_gnavus performed the best in differentiating between HC and CKD populations. In addition, this novel study found that the genera Holdemanella, Megamonas, Prevotella 2, Dielma, and Scardovia were associated with the progression of CKD and hemodialysis. In conclusion, the composition of gut microbiota was different in CKD populations compared with healthy populations, and Lachnospira and R._gnavus were better microbial biomarkers. In addition, five phylotypes, including Holdemanella, Megamonas, Prevotella2, Dielma, and Scardovia, served as an indicator of the progression of CKD and hemodialysis. However, large‐scale prospective studies should be performed to identify the reliability of the set of these phylotypes as biomarkers. |
topic |
chronic kidney disease gut microbiota hemodialysis intestinal dysbiosis microbial biomarker |
url |
https://doi.org/10.1002/mbo3.678 |
work_keys_str_mv |
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