Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells

Esculetin as a Bifunctional Antioxidant Prevents and Counteracts the Oxidative Stress and Neuronal Death Induced by Amyloid Protein in SH-SY5Y Cells

Oxidative stress (OS) appears to be an important determinant during the different stages of progression of Alzheimer’s Disease (AD). In particular, impaired antioxidant defense mechanisms, such as the decrease of glutathione (GSH) and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2), a mas...

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Bibliographic Details
Main Authors: Letizia Pruccoli, Fabiana Morroni, Giulia Sita, Patrizia Hrelia, Andrea Tarozzi
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Antioxidants
Subjects:
amyloid beta
oxidative stress
neuronal death
esculetin
bifunctional antioxidants
Online Access:https://www.mdpi.com/2076-3921/9/6/551

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