GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to ant...

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Main Authors:	Yapeng Li, Junfeng Gao, Mohammad Kamran, Laura Harmacek, Thomas Danhorn, Sonia M. Leach, Brian P. O’Connor, James R. Hagman, Hua Huang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-20766-0

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spelling	doaj-98ed13f7bcd445fca8318b9df4898a0f2021-01-24T12:12:15ZengNature Publishing GroupNature Communications2041-17232021-01-0112111710.1038/s41467-020-20766-0GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancersYapeng Li0Junfeng Gao1Mohammad Kamran2Laura Harmacek3Thomas Danhorn4Sonia M. Leach5Brian P. O’Connor6James R. Hagman7Hua Huang8Department of Immunology and Genomic Medicine, National Jewish HealthDepartment of Immunology and Genomic Medicine, National Jewish HealthDepartment of Immunology and Genomic Medicine, National Jewish HealthCenter for Genes, Environment and Health, National Jewish HealthCenter for Genes, Environment and Health, National Jewish HealthDepartment of Immunology and Genomic Medicine, National Jewish HealthCenter for Genes, Environment and Health, National Jewish HealthDepartment of Immunology and Genomic Medicine, National Jewish HealthDepartment of Immunology and Genomic Medicine, National Jewish HealthMast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.https://doi.org/10.1038/s41467-020-20766-0
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang
spellingShingle	Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers Nature Communications
author_facet	Yapeng Li Junfeng Gao Mohammad Kamran Laura Harmacek Thomas Danhorn Sonia M. Leach Brian P. O’Connor James R. Hagman Hua Huang
author_sort	Yapeng Li
title	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_short	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_full	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_fullStr	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_full_unstemmed	GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
title_sort	gata2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-01-01
description	Mast cells are critical effectors of allergic inflammation and protection against parasitic infections. Here the authors demonstrate that GATA2 promotes chromatin accessibility at the super-enhancers of mast cell identity genes and primes both typical and super-enhancers at genes that respond to antigenic stimulation.
url	https://doi.org/10.1038/s41467-020-20766-0
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GATA2 regulates mast cell identity and responsiveness to antigenic stimulation by promoting chromatin remodeling at super-enhancers

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