Functional Toll-Like Receptors (TLRs) Are Expressed by a Majority of Primary Human Acute Myeloid Leukemia Cells and Inducibility of the TLR Signaling Pathway Is Associated with a More Favorable Phenotype

Functional Toll-Like Receptors (TLRs) Are Expressed by a Majority of Primary Human Acute Myeloid Leukemia Cells and Inducibility of the TLR Signaling Pathway Is Associated with a More Favorable Phenotype

Acute myeloid leukemia (AML) is a highly heterogeneous disease with regard to biological characteristics and receptor expression. Toll-like receptors (TLRs) are upstream to the transcription factor NFκB and part of the innate immune system. They are differentially expressed on AML blasts, a...

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Bibliographic Details
Main Authors: Annette K. Brenner, Øystein Bruserud
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
acute myeloid leukemia
toll-like receptors
cytokine
epigenetic modification
survival
Online Access:https://www.mdpi.com/2072-6694/11/7/973

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