Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex

Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex

Summary: Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We...

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Main Authors: Marie H. Sabec, Susan Wonnacott, E. Clea Warburton, Zafar I. Bashir
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718303450
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spelling doaj-99073b3781a94932b0b8803245b505862020-11-24T21:54:51ZengElsevierCell Reports2211-12472018-03-01221334093415Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal CortexMarie H. Sabec0Susan Wonnacott1E. Clea Warburton2Zafar I. Bashir3School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UK; Corresponding authorDepartment of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UKSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UKSchool of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol BS8 1TD, UKSummary: Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We demonstrate that nAChRs in the prefrontal cortex exhibit subtype-specific roles in associative memory encoding and retrieval. We present evidence that these separate roles of nAChRs may rely on bidirectional modulation of plasticity at synaptic inputs to the prefrontal cortex that are essential for associative recognition memory. : Sabec et al. reveal a divergence in function of prefrontal nicotinic receptor subtypes in different stages of long-term associative recognition memory that relates to bidirectional modulation of synaptic plasticity at hippocampal-prefrontal synapses. Keywords: acetylcholine, nicotinic receptor, medial prefrontal cortex, associative recognition memory, plasticityhttp://www.sciencedirect.com/science/article/pii/S2211124718303450
collection DOAJ
language English
format Article
sources DOAJ
author Marie H. Sabec
Susan Wonnacott
E. Clea Warburton
Zafar I. Bashir
spellingShingle Marie H. Sabec
Susan Wonnacott
E. Clea Warburton
Zafar I. Bashir
Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
Cell Reports
author_facet Marie H. Sabec
Susan Wonnacott
E. Clea Warburton
Zafar I. Bashir
author_sort Marie H. Sabec
title Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
title_short Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
title_full Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
title_fullStr Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
title_full_unstemmed Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex
title_sort nicotinic acetylcholine receptors control encoding and retrieval of associative recognition memory through plasticity in the medial prefrontal cortex
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2018-03-01
description Summary: Nicotinic acetylcholine receptors (nAChRs) expressed in the medial prefrontal cortex have critical roles in cognitive function. However, whether nAChRs are required for associative recognition memory and the mechanisms by which nAChRs may contribute to mnemonic processing are not known. We demonstrate that nAChRs in the prefrontal cortex exhibit subtype-specific roles in associative memory encoding and retrieval. We present evidence that these separate roles of nAChRs may rely on bidirectional modulation of plasticity at synaptic inputs to the prefrontal cortex that are essential for associative recognition memory. : Sabec et al. reveal a divergence in function of prefrontal nicotinic receptor subtypes in different stages of long-term associative recognition memory that relates to bidirectional modulation of synaptic plasticity at hippocampal-prefrontal synapses. Keywords: acetylcholine, nicotinic receptor, medial prefrontal cortex, associative recognition memory, plasticity
url http://www.sciencedirect.com/science/article/pii/S2211124718303450
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