Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus
Cadmium is the second most hazardous metals with bio-concentration factor (BCF) > 100 Although WHO permitted cadmium concentration in drinking water is 0.005 mg/L, yet the reality is far above to this limit because of industrial utility of this metal. Oral exposure of cadmium to human results in...
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doaj-991061c55a6140a7b4caf257fa99eede2020-11-25T00:45:00ZengElsevierSaudi Journal of Biological Sciences1319-562X2018-12-0125817391742Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseusMohammad Hashim0Baby Tabassum1Elsayed Fathi Abd_Allah2Abeer Hashem3Priya Bajaj4Toxicology Laboratory, Department of Zoology, Govt. Raza P.G. College, Rampur, UP 244091, India; Corresponding author.Toxicology Laboratory, Department of Zoology, Govt. Raza P.G. College, Rampur, UP 244091, IndiaPlant Production Department, College of Food and Agricultural Sciences, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi ArabiaBotany and Microbiology Department, College of Science, King Saud University, P.O. Box. 2460, Riyadh 11451, Saudi Arabia; Mycology and Plant Disease Survey Department, Plant Pathology Research Institute, Agriculture Research Center, Giza, EgyptToxicology Laboratory, Department of Zoology, Govt. Raza P.G. College, Rampur, UP 244091, IndiaCadmium is the second most hazardous metals with bio-concentration factor (BCF) > 100 Although WHO permitted cadmium concentration in drinking water is 0.005 mg/L, yet the reality is far above to this limit because of industrial utility of this metal. Oral exposure of cadmium to human results in dreadful symptoms of metabolic disorders especially in liver and kidneys. Endogenous protection could be supported by some exogenous herbal supplement (viz., Catharanthus roseus in this case) to overcome the toxic effects. Present Study has been designed to find out the functional renal changes under the effect of cadmium and Catharanthus roseus in the model organism albino rats. Cadmium significantly (p > 0.01) increases the level of nitrogenous waste (Urea, BUN, Uric Acid and Creatinin), while decreases the serum protein profile in acute and sub-acute sets. Urea concentration of control ranged from 16.56 to 17.72 mg/dl while that of Group-B and D were 19.84 to 20.87 mg/dl and 17.56 to 17.59 mg/dl respectively. Similarly uric acid concentration ranged in control form 6.98 to 8.01 mg/dl in group-B from 7.58 to 10.25 mg/dl, in Group-D 8.02 to 8.59 mg/dl respectively. Creatinin concentration ranged in control 0.57 to 0.65 mg/dl, in group-B 0.97 to 1.02 mg/dl, in group-D – 0.95 to 0.98 mg/dl respectively.These results might be due to altered filtration rate of kidney because of protein disruption. The studies conclude the efficient nephro-protection offered by Catharanthus roseus extract against Cadmium toxicity. Keywords: Cadmium, Catharanthus roseus, Nephrotoxicity, Rattus norvegicushttp://www.sciencedirect.com/science/article/pii/S1319562X18302274 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Hashim Baby Tabassum Elsayed Fathi Abd_Allah Abeer Hashem Priya Bajaj |
spellingShingle |
Mohammad Hashim Baby Tabassum Elsayed Fathi Abd_Allah Abeer Hashem Priya Bajaj Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus Saudi Journal of Biological Sciences |
author_facet |
Mohammad Hashim Baby Tabassum Elsayed Fathi Abd_Allah Abeer Hashem Priya Bajaj |
author_sort |
Mohammad Hashim |
title |
Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus |
title_short |
Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus |
title_full |
Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus |
title_fullStr |
Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus |
title_full_unstemmed |
Bioremediation of cadmium induced renal toxicity in Rattus norvegicus by medicinal plant Catharanthus roseus |
title_sort |
bioremediation of cadmium induced renal toxicity in rattus norvegicus by medicinal plant catharanthus roseus |
publisher |
Elsevier |
series |
Saudi Journal of Biological Sciences |
issn |
1319-562X |
publishDate |
2018-12-01 |
description |
Cadmium is the second most hazardous metals with bio-concentration factor (BCF) > 100 Although WHO permitted cadmium concentration in drinking water is 0.005 mg/L, yet the reality is far above to this limit because of industrial utility of this metal. Oral exposure of cadmium to human results in dreadful symptoms of metabolic disorders especially in liver and kidneys. Endogenous protection could be supported by some exogenous herbal supplement (viz., Catharanthus roseus in this case) to overcome the toxic effects. Present Study has been designed to find out the functional renal changes under the effect of cadmium and Catharanthus roseus in the model organism albino rats. Cadmium significantly (p > 0.01) increases the level of nitrogenous waste (Urea, BUN, Uric Acid and Creatinin), while decreases the serum protein profile in acute and sub-acute sets. Urea concentration of control ranged from 16.56 to 17.72 mg/dl while that of Group-B and D were 19.84 to 20.87 mg/dl and 17.56 to 17.59 mg/dl respectively. Similarly uric acid concentration ranged in control form 6.98 to 8.01 mg/dl in group-B from 7.58 to 10.25 mg/dl, in Group-D 8.02 to 8.59 mg/dl respectively. Creatinin concentration ranged in control 0.57 to 0.65 mg/dl, in group-B 0.97 to 1.02 mg/dl, in group-D – 0.95 to 0.98 mg/dl respectively.These results might be due to altered filtration rate of kidney because of protein disruption. The studies conclude the efficient nephro-protection offered by Catharanthus roseus extract against Cadmium toxicity. Keywords: Cadmium, Catharanthus roseus, Nephrotoxicity, Rattus norvegicus |
url |
http://www.sciencedirect.com/science/article/pii/S1319562X18302274 |
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