A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts
Background and Objective. Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the...
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doaj-9919d716cf9c4bb9a50c86245edb78872020-11-25T00:12:47ZengHindawi LimitedDisease Markers0278-02401875-86302018-01-01201810.1155/2018/70485317048531A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous CystsLuisana Brito-Mendoza0Ronell Bologna-Molina1María Esther Irigoyen-Camacho2Guillermo Martinez3Celeste Sánchez-Romero4Adalberto Mosqueda-Taylor5Oral Medicine and Pathology Postgraduate Program, Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Mexico City, MexicoMolecular Pathology, Faculty of Dentistry, Universidad de la República, Montevideo, UruguayOral Medicine and Pathology Postgraduate Program, Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Mexico City, MexicoOral Medicine and Pathology Postgraduate Program, Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Mexico City, MexicoOral Pathology, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, BrazilOral Medicine and Pathology Postgraduate Program, Health Care Department, Universidad Autónoma Metropolitana Xochimilco, Mexico City, MexicoBackground and Objective. Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). Methods. Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA). Results. A higher expression of Ki-67 was identified in OKC as compared to UA (p<0.0001). UA exhibited a greater loss of CD138 expression versus OKCs (p>0.0034). RANKL was expressed higher in the epithelium (p=0.0002) and in the stroma (p=0.0004) of UA. DC had a lower expression of these markers. Conclusion. Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth. The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities.http://dx.doi.org/10.1155/2018/7048531 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Luisana Brito-Mendoza Ronell Bologna-Molina María Esther Irigoyen-Camacho Guillermo Martinez Celeste Sánchez-Romero Adalberto Mosqueda-Taylor |
spellingShingle |
Luisana Brito-Mendoza Ronell Bologna-Molina María Esther Irigoyen-Camacho Guillermo Martinez Celeste Sánchez-Romero Adalberto Mosqueda-Taylor A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts Disease Markers |
author_facet |
Luisana Brito-Mendoza Ronell Bologna-Molina María Esther Irigoyen-Camacho Guillermo Martinez Celeste Sánchez-Romero Adalberto Mosqueda-Taylor |
author_sort |
Luisana Brito-Mendoza |
title |
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts |
title_short |
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts |
title_full |
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts |
title_fullStr |
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts |
title_full_unstemmed |
A Comparison of Ki67, Syndecan-1 (CD138), and Molecular RANK, RANKL, and OPG Triad Expression in Odontogenic Keratocyts, Unicystic Ameloblastoma, and Dentigerous Cysts |
title_sort |
comparison of ki67, syndecan-1 (cd138), and molecular rank, rankl, and opg triad expression in odontogenic keratocyts, unicystic ameloblastoma, and dentigerous cysts |
publisher |
Hindawi Limited |
series |
Disease Markers |
issn |
0278-0240 1875-8630 |
publishDate |
2018-01-01 |
description |
Background and Objective. Reduced expression of syndecan-1 (CD138), increased proliferation index, and modifications in the expression of the molecular RANK/RANKL/OPG triad are related to an intensified potential of aggressiveness and invasion of diverse tumors and cysts. The aim was to compare the expression of Ki-67, CD138, and the molecular triad RANK, RANKL, and OPG in odontogenic keratocysts (OKC), unicystic ameloblastomas (UA), and dentigerous cysts (DC). Methods. Immunohistochemistry for Ki-67, CD138, RANK, RANKL, and OPG was performed in 58 odontogenic cystic lesions (22 OKC, 17 DC, and 19 UA). Results. A higher expression of Ki-67 was identified in OKC as compared to UA (p<0.0001). UA exhibited a greater loss of CD138 expression versus OKCs (p>0.0034). RANKL was expressed higher in the epithelium (p=0.0002) and in the stroma (p=0.0004) of UA. DC had a lower expression of these markers. Conclusion. Higher RANKL expression together with the reduction on CD138 expression in UA could be linked to a greater invasive and destructive potential, while the increased proliferation rate observed in OKC could be related to its continuous intrabony growth. The expansion of DC does not seem to be related to such factors, justifying the different therapeutic approaches proposed for each of these entities. |
url |
http://dx.doi.org/10.1155/2018/7048531 |
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