Altered sugar donor specificity and catalytic activity of pteridine glycosyltransferases by domain swapping or site-directed mutagenesis
CY-007 and CY-049 pteridine glycosyltransferases (PGTs) thatdiffer in sugar donor specificity to catalyze either glucose orxylose transfer to tetrahydrobiopterin were studied here touncover the structural determinants necessary for the specificity.The importance of the C-terminal domain and its resi...
Main Authors: | Hye-Lim Kim, Ae Hyun Kim, Mi Bi Park, Soo-Woong Lee, Young Shik Park |
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Format: | Article |
Language: | English |
Published: |
Korean Society for Biochemistry and Molecular Biology
2013-01-01
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Series: | BMB Reports |
Subjects: | |
Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI2MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0xJTVEMTMwMTI5MjExNF8lMjgwMzctMDQwJTI5Qk1CXzEyLTE0Ny5wZGY= |
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