Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats
Abstract Background Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormali...
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doaj-99296b673a6045ba87cea7db7ed306292020-11-25T02:02:17ZengBMCLipids in Health and Disease1476-511X2020-04-011911710.1186/s12944-020-01228-4Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic ratsShahla Rezaei0Fatemeh Ashkar1Farhad Koohpeyma2Marzieh Mahmoodi3Maryam Gholamalizadeh4Zohreh Mazloom5Saeid Doaei6Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical SciencesStudent Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical SciencesShiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical SciencesStudent Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical SciencesStudents Research Committee, Cancer Research Center, Shahid Beheshti University of Medical SciencesDepartment of Nutrition, School of Health and Nutrition, Shiraz University of Medical SciencesResearch Center of Health and Environment, Guilan University of Medical SciencesAbstract Background Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormality, and glycemic control in diabetic rats. Methods Rats were randomly assigned to 7 groups of 10 animals. Diabetes was induced by injection of streptozotocin (STZ) to 4 groups of rats. Three groups of diabetic rats were given 250 mg/kg/day metformin, 25 mg/kg/day Achillea millefolium hydroalcoholic extract, or 100 mg/kg/day of this extract. Two non-diabetic groups were also given either 25 mg/kg/day or 100 mg/kg/day Achillea millefolium extract. Normal control and diabetic control rats received 1 mL/day of normal saline. Treatments were administered through oral gavage for 28 days. At the end, rats were anesthetized with ether and their serum samples were separated in order to measure blood glucose, serum total protein, lipids, and liver enzymes. Results There was a significant reduction in blood glucose, serum liver enzymes, triglycerides, and total- and LDL-cholesterol levels of the Achillea millefolium extract-treated groups compared to the other groups. In addition, there was a significant increment in body weight and HDL-cholesterol serum level in the Achillea millefolium-treated groups. Conclusion Achillea millefolium extract compared to metformin reduces lipid abnormality, blood glucose and liver enzymes in STZ-induced diabetic rats. Future clinical studies are warranted to confirm our experimental findings in humans.http://link.springer.com/article/10.1186/s12944-020-01228-4Achillea millefoliumBlood glucoseLipid profileLiver enzymesDiabetes |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Shahla Rezaei Fatemeh Ashkar Farhad Koohpeyma Marzieh Mahmoodi Maryam Gholamalizadeh Zohreh Mazloom Saeid Doaei |
spellingShingle |
Shahla Rezaei Fatemeh Ashkar Farhad Koohpeyma Marzieh Mahmoodi Maryam Gholamalizadeh Zohreh Mazloom Saeid Doaei Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats Lipids in Health and Disease Achillea millefolium Blood glucose Lipid profile Liver enzymes Diabetes |
author_facet |
Shahla Rezaei Fatemeh Ashkar Farhad Koohpeyma Marzieh Mahmoodi Maryam Gholamalizadeh Zohreh Mazloom Saeid Doaei |
author_sort |
Shahla Rezaei |
title |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
title_short |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
title_full |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
title_fullStr |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
title_full_unstemmed |
Hydroalcoholic extract of Achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
title_sort |
hydroalcoholic extract of achillea millefolium improved blood glucose, liver enzymes and lipid profile compared to metformin in streptozotocin-induced diabetic rats |
publisher |
BMC |
series |
Lipids in Health and Disease |
issn |
1476-511X |
publishDate |
2020-04-01 |
description |
Abstract Background Recent studies have reported that herbal extracts may have some protective effect against the complications of diabetes mellitus. This study aimed to investigate the effects of Achillea millefolium hydroalcoholic extract in comparison to metformin on liver damage, lipid abnormality, and glycemic control in diabetic rats. Methods Rats were randomly assigned to 7 groups of 10 animals. Diabetes was induced by injection of streptozotocin (STZ) to 4 groups of rats. Three groups of diabetic rats were given 250 mg/kg/day metformin, 25 mg/kg/day Achillea millefolium hydroalcoholic extract, or 100 mg/kg/day of this extract. Two non-diabetic groups were also given either 25 mg/kg/day or 100 mg/kg/day Achillea millefolium extract. Normal control and diabetic control rats received 1 mL/day of normal saline. Treatments were administered through oral gavage for 28 days. At the end, rats were anesthetized with ether and their serum samples were separated in order to measure blood glucose, serum total protein, lipids, and liver enzymes. Results There was a significant reduction in blood glucose, serum liver enzymes, triglycerides, and total- and LDL-cholesterol levels of the Achillea millefolium extract-treated groups compared to the other groups. In addition, there was a significant increment in body weight and HDL-cholesterol serum level in the Achillea millefolium-treated groups. Conclusion Achillea millefolium extract compared to metformin reduces lipid abnormality, blood glucose and liver enzymes in STZ-induced diabetic rats. Future clinical studies are warranted to confirm our experimental findings in humans. |
topic |
Achillea millefolium Blood glucose Lipid profile Liver enzymes Diabetes |
url |
http://link.springer.com/article/10.1186/s12944-020-01228-4 |
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