Aging-associated distinctive DNA methylation changes of LINE-1 retrotransposons in pure cell-free DNA from human blood
Abstract LINE-1 hypomethylation of cell-free DNA has been described as an epigenetic biomarker of human aging. However, in the past, insufficient differentiation between cellular and cell-free DNA may have confounded analyses of genome-wide methylation levels in aging cells. Here we present a new me...
Main Authors: | Wardah Mahmood, Lars Erichsen, Pauline Ott, Wolfgang A. Schulz, Johannes C. Fischer, Marcos J. Arauzo-Bravo, Marcelo L. Bendhack, Mohamed Hassan, Simeon Santourlidis |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-12-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-020-79126-z |
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