Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo
This case report is about a 48-year-old female patient with systemic amyloidosis and multiple myeloma simultaneously. Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among others. She...
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Sociedade Brasileira de Dermatologia
2012-02-01
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doaj-994fb81e59cb4be184382e99ce0c68eb2020-11-24T22:49:00ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05961806-48412012-02-0187111912210.1590/S0365-05962012000100015Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiploEderson Valei Lopes de OliveiraAna Carolina Garcia PozettiEurides Maria de Oliveira PozettiJoão Roberto AntonioNilceo Schwery MichalanyThis case report is about a 48-year-old female patient with systemic amyloidosis and multiple myeloma simultaneously. Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among others. She had presented intermittent papular lesions on the upper eyelids one year before, which worsened following local trauma. A local skin biopsy showed amorphous and eosinophilic substance in the dermis. Congo red staining confirmed the amyloid deposits. Abnormal exams: proteinuria (570mg/24h), Bence-Jones proteinuria and clonal plasma cells (70%) found in myelogram. Following the diagnosis of multiple myeloma based on amyloid skin lesions, the patient was referred to the Hematology service and died 5 months after the diagnosis.<br>Relatamos um caso de uma paciente de 48 anos com amiloidose sistêmica associada a mieloma múltiplo. Lesões infiltrativas cutâneas como pápulas, nódulos ou placas com aspecto sero-hemorrágico podem ser localizados nas pálpebras, pescoço, região retroauricular dentre outras. No presente caso, as pálpebras foram acometidas por pápulas, há 1 ano, de caráter intermitente e piora após trauma local. Biópsia local evidenciou material amorfo e eosinofílico na derme. A coloração vermelho do Congo confirmou presença de substância amiloide. Exames anormais: proteinúria de 570mg/24 horas, proteinúria de Bence-Jones positiva e mielograma com 70% de plasmócitos atípicos. Assim, realizou-se o diagnóstico de mieloma múltiplo a partir de manifestações cutâneas de amiloidose. Paciente encaminhada ao serviço de hematologia e foi a óbito em 5 meses.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000100015AmiloidoseMieloma múltiploPálpebrasPeleAmyloidosisEyelidsMultiple myelomaSkin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ederson Valei Lopes de Oliveira Ana Carolina Garcia Pozetti Eurides Maria de Oliveira Pozetti João Roberto Antonio Nilceo Schwery Michalany |
spellingShingle |
Ederson Valei Lopes de Oliveira Ana Carolina Garcia Pozetti Eurides Maria de Oliveira Pozetti João Roberto Antonio Nilceo Schwery Michalany Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo Anais Brasileiros de Dermatologia Amiloidose Mieloma múltiplo Pálpebras Pele Amyloidosis Eyelids Multiple myeloma Skin |
author_facet |
Ederson Valei Lopes de Oliveira Ana Carolina Garcia Pozetti Eurides Maria de Oliveira Pozetti João Roberto Antonio Nilceo Schwery Michalany |
author_sort |
Ederson Valei Lopes de Oliveira |
title |
Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo |
title_short |
Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo |
title_full |
Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo |
title_fullStr |
Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo |
title_full_unstemmed |
Primary systemic amyloidosis associated with multiple myeloma Amiloidose sistêmica primária associada ao mieloma múltiplo |
title_sort |
primary systemic amyloidosis associated with multiple myeloma amiloidose sistêmica primária associada ao mieloma múltiplo |
publisher |
Sociedade Brasileira de Dermatologia |
series |
Anais Brasileiros de Dermatologia |
issn |
0365-0596 1806-4841 |
publishDate |
2012-02-01 |
description |
This case report is about a 48-year-old female patient with systemic amyloidosis and multiple myeloma simultaneously. Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among others. She had presented intermittent papular lesions on the upper eyelids one year before, which worsened following local trauma. A local skin biopsy showed amorphous and eosinophilic substance in the dermis. Congo red staining confirmed the amyloid deposits. Abnormal exams: proteinuria (570mg/24h), Bence-Jones proteinuria and clonal plasma cells (70%) found in myelogram. Following the diagnosis of multiple myeloma based on amyloid skin lesions, the patient was referred to the Hematology service and died 5 months after the diagnosis.<br>Relatamos um caso de uma paciente de 48 anos com amiloidose sistêmica associada a mieloma múltiplo. Lesões infiltrativas cutâneas como pápulas, nódulos ou placas com aspecto sero-hemorrágico podem ser localizados nas pálpebras, pescoço, região retroauricular dentre outras. No presente caso, as pálpebras foram acometidas por pápulas, há 1 ano, de caráter intermitente e piora após trauma local. Biópsia local evidenciou material amorfo e eosinofílico na derme. A coloração vermelho do Congo confirmou presença de substância amiloide. Exames anormais: proteinúria de 570mg/24 horas, proteinúria de Bence-Jones positiva e mielograma com 70% de plasmócitos atípicos. Assim, realizou-se o diagnóstico de mieloma múltiplo a partir de manifestações cutâneas de amiloidose. Paciente encaminhada ao serviço de hematologia e foi a óbito em 5 meses. |
topic |
Amiloidose Mieloma múltiplo Pálpebras Pele Amyloidosis Eyelids Multiple myeloma Skin |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962012000100015 |
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