The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice.
Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental die...
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doaj-9954323755c54150bc495f398d6a13ef2020-11-24T20:45:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011111e016617510.1371/journal.pone.0166175The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice.Jonathan HewSamantha M Solon-BietAisling C McMahonKari RuohonenDavid RaubenheimerJ William O BallardDavid G Le CouteurCaroline NichollsZhe LiPeter K M MaitzYiwei WangStephen J SimpsonNutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous fat thickness varied positively with fat intake, due to enlarged adipocytes rather than increased adipocyte number. We therefore demonstrated clear interactions between skin structure and macronutrient intakes, with the associations being sex-specific and dependent on dietary macronutrient balance.http://europepmc.org/articles/PMC5104383?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan Hew Samantha M Solon-Biet Aisling C McMahon Kari Ruohonen David Raubenheimer J William O Ballard David G Le Couteur Caroline Nicholls Zhe Li Peter K M Maitz Yiwei Wang Stephen J Simpson |
spellingShingle |
Jonathan Hew Samantha M Solon-Biet Aisling C McMahon Kari Ruohonen David Raubenheimer J William O Ballard David G Le Couteur Caroline Nicholls Zhe Li Peter K M Maitz Yiwei Wang Stephen J Simpson The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. PLoS ONE |
author_facet |
Jonathan Hew Samantha M Solon-Biet Aisling C McMahon Kari Ruohonen David Raubenheimer J William O Ballard David G Le Couteur Caroline Nicholls Zhe Li Peter K M Maitz Yiwei Wang Stephen J Simpson |
author_sort |
Jonathan Hew |
title |
The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. |
title_short |
The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. |
title_full |
The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. |
title_fullStr |
The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. |
title_full_unstemmed |
The Effects of Dietary Macronutrient Balance on Skin Structure in Aging Male and Female Mice. |
title_sort |
effects of dietary macronutrient balance on skin structure in aging male and female mice. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2016-01-01 |
description |
Nutrition influences skin structure; however, a systematic investigation into how energy and macronutrients (protein, carbohydrate and fat) affects the skin has yet to be conducted. We evaluated the associations between macronutrients, energy intake and skin structure in mice fed 25 experimental diets and a control diet for 15 months using the Geometric Framework, a novel method of nutritional analysis. Skin structure was associated with the ratio of dietary macronutrients eaten, not energy intake, and the nature of the effect differed between the sexes. In males, skin structure was primarily associated with protein intake, whereas in females carbohydrate intake was the primary correlate. In both sexes, the dermis and subcutaneous fat thicknesses were inversely proportional. Subcutaneous fat thickness varied positively with fat intake, due to enlarged adipocytes rather than increased adipocyte number. We therefore demonstrated clear interactions between skin structure and macronutrient intakes, with the associations being sex-specific and dependent on dietary macronutrient balance. |
url |
http://europepmc.org/articles/PMC5104383?pdf=render |
work_keys_str_mv |
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