<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology
Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to charact...
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/2071 |
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doaj-995714cefc644d42a874702907ba23422021-02-20T00:05:23ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01222071207110.3390/ijms22042071<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular BiologyElvira Forte0Michael A. McLellan1Daniel A. Skelly2Nadia A. Rosenthal3The Jackson Laboratory, Bar Harbor, ME 04609, USAThe Jackson Laboratory, Bar Harbor, ME 04609, USAThe Jackson Laboratory, Bar Harbor, ME 04609, USAThe Jackson Laboratory, Bar Harbor, ME 04609, USARecent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium.https://www.mdpi.com/1422-0067/22/4/2071heartcardiacsingle-cellscRNAseqdifferentiationdevelopment |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Elvira Forte Michael A. McLellan Daniel A. Skelly Nadia A. Rosenthal |
| spellingShingle |
Elvira Forte Michael A. McLellan Daniel A. Skelly Nadia A. Rosenthal <i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology International Journal of Molecular Sciences heart cardiac single-cell scRNAseq differentiation development |
| author_facet |
Elvira Forte Michael A. McLellan Daniel A. Skelly Nadia A. Rosenthal |
| author_sort |
Elvira Forte |
| title |
<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology |
| title_short |
<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology |
| title_full |
<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology |
| title_fullStr |
<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology |
| title_full_unstemmed |
<i>Ex uno, plures</i>–From One Tissue to Many Cells: A Review of Single-Cell Transcriptomics in Cardiovascular Biology |
| title_sort |
<i>ex uno, plures</i>–from one tissue to many cells: a review of single-cell transcriptomics in cardiovascular biology |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1661-6596 1422-0067 |
| publishDate |
2021-02-01 |
| description |
Recent technological advances have revolutionized the study of tissue biology and garnered a greater appreciation for tissue complexity. In order to understand cardiac development, heart tissue homeostasis, and the effects of stress and injury on the cardiovascular system, it is essential to characterize the heart at high cellular resolution. Single-cell profiling provides a more precise definition of tissue composition, cell differentiation trajectories, and intercellular communication, compared to classical bulk approaches. Here, we aim to review how recent single-cell multi-omic studies have changed our understanding of cell dynamics during cardiac development, and in the healthy and diseased adult myocardium. |
| topic |
heart cardiac single-cell scRNAseq differentiation development |
| url |
https://www.mdpi.com/1422-0067/22/4/2071 |
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