Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review
Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current eviden...
Main Authors: | , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2021-03-01
|
Series: | World Allergy Organization Journal |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455120304063 |
id |
doaj-995bc60ea0df4623a2b902b459e60d7e |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefania Arasi Ulugbek Nurmatov Audrey Dunn-Galvin Shahd Daher Graham Roberts Paul J. Turner Sayantani B. Shinder Ruchi Gupta Philippe Eigenmann Anna Nowak-Wegrzyn Mario A. Sánchez Borges Ignacio J. Ansotegui Montserrat Fernandez-Rivas Stavros Petrou Luciana Kase Tanno Marta Vazquez-Ortiz Brian P. Vickery Gary Wing-Kin Wong Motohiro Ebisawa Alessandro Fiocchi |
spellingShingle |
Stefania Arasi Ulugbek Nurmatov Audrey Dunn-Galvin Shahd Daher Graham Roberts Paul J. Turner Sayantani B. Shinder Ruchi Gupta Philippe Eigenmann Anna Nowak-Wegrzyn Mario A. Sánchez Borges Ignacio J. Ansotegui Montserrat Fernandez-Rivas Stavros Petrou Luciana Kase Tanno Marta Vazquez-Ortiz Brian P. Vickery Gary Wing-Kin Wong Motohiro Ebisawa Alessandro Fiocchi Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review World Allergy Organization Journal Definition Food allergy Severity Systematic review Mixed-methods study |
author_facet |
Stefania Arasi Ulugbek Nurmatov Audrey Dunn-Galvin Shahd Daher Graham Roberts Paul J. Turner Sayantani B. Shinder Ruchi Gupta Philippe Eigenmann Anna Nowak-Wegrzyn Mario A. Sánchez Borges Ignacio J. Ansotegui Montserrat Fernandez-Rivas Stavros Petrou Luciana Kase Tanno Marta Vazquez-Ortiz Brian P. Vickery Gary Wing-Kin Wong Motohiro Ebisawa Alessandro Fiocchi |
author_sort |
Stefania Arasi |
title |
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review |
title_short |
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review |
title_full |
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review |
title_fullStr |
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review |
title_full_unstemmed |
Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic review |
title_sort |
consensus on definition of food allergy severity (defase) an integrated mixed methods systematic review |
publisher |
Elsevier |
series |
World Allergy Organization Journal |
issn |
1939-4551 |
publishDate |
2021-03-01 |
description |
Background and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We undertook a mixed-methods systematic review, which involved searching 11 international biomedical databases for published studies from inception to 31 December 2019. Studies were independently screened against pre-defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta-analyses and, therefore, narrative synthesis of quantitative and qualitative data was performed. Results: We found 23 studies providing eligible primary data on symptom-specific severity of food allergic reactions, and 31 previously published symptom-severity scoring systems referred to food allergic reactions. There were seven studies which assessed quality-of-life measures in patients (and family members) with different food allergy severity and two studies that investigated the economic burden of food allergy severity. Overall, the quality and the global rating of all included studies were judged as being moderate. Conclusions: There is heterogeneity among severity scoring systems used and even outcomes considered in the context of severity of food allergy. No score has been validated. Our results will be used to inform the development of an international consensus to define the severity of food allergy. Systematic review registration: A protocol was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) database with the registration number CRD42020183103 (https://www.crd.york.ac.uk/prospero/#recordDetails). |
topic |
Definition Food allergy Severity Systematic review Mixed-methods study |
url |
http://www.sciencedirect.com/science/article/pii/S1939455120304063 |
work_keys_str_mv |
AT stefaniaarasi consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT ulugbeknurmatov consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT audreydunngalvin consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT shahddaher consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT grahamroberts consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT pauljturner consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT sayantanibshinder consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT ruchigupta consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT philippeeigenmann consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT annanowakwegrzyn consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT marioasanchezborges consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT ignaciojansotegui consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT montserratfernandezrivas consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT stavrospetrou consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT lucianakasetanno consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT martavazquezortiz consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT brianpvickery consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT garywingkinwong consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT motohiroebisawa consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview AT alessandrofiocchi consensusondefinitionoffoodallergyseveritydefaseanintegratedmixedmethodssystematicreview |
_version_ |
1721538709566783488 |
spelling |
doaj-995bc60ea0df4623a2b902b459e60d7e2021-04-06T04:03:31ZengElsevierWorld Allergy Organization Journal1939-45512021-03-01143100503Consensus on DEfinition of Food Allergy SEverity (DEFASE) an integrated mixed methods systematic reviewStefania Arasi0Ulugbek Nurmatov1Audrey Dunn-Galvin2Shahd Daher3Graham Roberts4Paul J. Turner5Sayantani B. Shinder6Ruchi Gupta7Philippe Eigenmann8Anna Nowak-Wegrzyn9Mario A. Sánchez Borges10Ignacio J. Ansotegui11Montserrat Fernandez-Rivas12Stavros Petrou13Luciana Kase Tanno14Marta Vazquez-Ortiz15Brian P. Vickery16Gary Wing-Kin Wong17Motohiro Ebisawa18Alessandro Fiocchi19Allergy Unit - Area of Translational Research in Pediatric Specialities, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy; Corresponding author. Pediatric Allergology Unit, Bambino Gesù Hospital (IRCCS), Piazza S. Onofrio, Rome, 00161, Italy.Division of Population Medicine, School of Medicine, Cardiff University, Wales, UKApplied Psychology and Paediatrics and Child Health, University College Cork, Cork, IrelandNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UKNIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Clinical and Experimental Sciences and Human Development in Health, Faculty of Medicine, University of Southampton, Southampton, UK; The David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, UKNational Heart & Lung Institute, Imperial College London, London, UK; Discipline of Paediatrics and Child Health, School of Medicine, University of Sydney, Sydney, AustraliaDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Stanford University, Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, CA, USACenter for Food Allergy and Asthma Research (CFAAR), Northwestern University Feinberg School of Medicine, Department of Pediatrics & Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, USAPediatric Allergy Unit, Department of Women-Children-Teenagers Pediatrics, University Hospitals of Geneva, Geneva, SwitzerlandAllergy and Immunology, Department of Pediatrics, New York University School of Medicine, Langone Health, New York, NY, USA; Department of Pediatrics, Gastroenterology and Nutrition, Collegium Medicum, University of Warmia and Mazury, Olsztyn, PolandAllergy and Clinical Immunology Department, Centro Médico Docente La Trinidad, Caracas, VenezuelaDepartment Allergy and Immunology, Hospital Quironsalud Bizkaia, Bilbao, SpainServicio de Alergia, Hospital Clınico San Carlos, UCM, IdISSC, ARADyAL, Madrid, SpainNuffield Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, England, UKHospital Sírio Libanês, São Paulo, Brazil; University Hospital of Montpellier, Montpellier, France; Sorbonne Universités, Paris, FranceDepartment of Paediatrics, Imperial College London, United KingdomDepartment of Pediatrics, Emory University, Atlanta, GA, USADepartment of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, ChinaClinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Kanagawa, JapanAllergy Unit - Area of Translational Research in Pediatric Specialities, Bambino Gesù Children's Hospital, IRCCS, Rome, ItalyBackground and aims: The term “Food Allergy” refers to a complex global health problem with a wide spectrum of severity. However, a uniform definition of severe food allergy is currently missing. This systematic review is the preliminary step towards a state-of-the-art synopsis of the current evidence relating to the severity of IgE-mediated food allergy; it will inform attempts to develop a consensus to define food allergy severity by clinicians and other stakeholders. Methods: We undertook a mixed-methods systematic review, which involved searching 11 international biomedical databases for published studies from inception to 31 December 2019. Studies were independently screened against pre-defined eligibility criteria and critically appraised by established instruments. The substantial heterogeneity of included studies precluded meta-analyses and, therefore, narrative synthesis of quantitative and qualitative data was performed. Results: We found 23 studies providing eligible primary data on symptom-specific severity of food allergic reactions, and 31 previously published symptom-severity scoring systems referred to food allergic reactions. There were seven studies which assessed quality-of-life measures in patients (and family members) with different food allergy severity and two studies that investigated the economic burden of food allergy severity. Overall, the quality and the global rating of all included studies were judged as being moderate. Conclusions: There is heterogeneity among severity scoring systems used and even outcomes considered in the context of severity of food allergy. No score has been validated. Our results will be used to inform the development of an international consensus to define the severity of food allergy. Systematic review registration: A protocol was prospectively registered with the International Prospective Register of Systematic Reviews (PROSPERO) database with the registration number CRD42020183103 (https://www.crd.york.ac.uk/prospero/#recordDetails).http://www.sciencedirect.com/science/article/pii/S1939455120304063DefinitionFood allergySeveritySystematic reviewMixed-methods study |