Influence of Delayed Conductance on Neuronal Synchronization
In the brain, the excitation-inhibition balance prevents abnormal synchronous behavior. However, known synaptic conductance intensity can be insufficient to account for the undesired synchronization. Due to this fact, we consider time delay in excitatory and inhibitory conductances and study its eff...
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doaj-9967d197949449fa8773900e1efd0d052020-11-25T02:44:18ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2020-09-011110.3389/fphys.2020.01053551596Influence of Delayed Conductance on Neuronal SynchronizationPaulo R. Protachevicz0Paulo R. Protachevicz1Fernando S. Borges2Kelly C. Iarosz3Kelly C. Iarosz4Kelly C. Iarosz5Murilo S. Baptista6Ewandson L. Lameu7Matheus Hansen8Matheus Hansen9Iberê L. Caldas10José D. Szezech11José D. Szezech12Antonio M. Batista13Antonio M. Batista14Antonio M. Batista15Jürgen Kurths16Jürgen Kurths17Jürgen Kurths18Instituto de Física, Universidade de São Paulo, São Paulo, BrazilGraduate Program in Science–Physics, State University of Ponta Grossa, Ponta Grossa, BrazilCenter for Mathematics, Computation, and Cognition, Federal University of ABC, São Paulo, BrazilInstituto de Física, Universidade de São Paulo, São Paulo, BrazilFaculdade de Telêmaco Borba, FATEB, Telêmaco Borba, BrazilGraduate Program in Chemical Engineering, Federal Technological University of Paraná, Ponta Grossa, BrazilInstitute for Complex Systems and Mathematical Biology, SUPA, University of Aberdeen, Aberdeen, United KingdomCell Biology and Anatomy Department, University of Calgary, Calgary, AB, CanadaGraduate Program in Science–Physics, State University of Ponta Grossa, Ponta Grossa, BrazilDepartment of Mathematics and Statistics, State University of Ponta Grossa, Ponta Grossa, BrazilInstituto de Física, Universidade de São Paulo, São Paulo, BrazilGraduate Program in Science–Physics, State University of Ponta Grossa, Ponta Grossa, BrazilDepartment of Mathematics and Statistics, State University of Ponta Grossa, Ponta Grossa, BrazilInstituto de Física, Universidade de São Paulo, São Paulo, BrazilGraduate Program in Science–Physics, State University of Ponta Grossa, Ponta Grossa, BrazilDepartment of Mathematics and Statistics, State University of Ponta Grossa, Ponta Grossa, BrazilDepartment of Physics, Humboldt University, Berlin, Germany0Department Complexity Science, Potsdam Institute for Climate Impact Research, Potsdam, Germany1Department of Human and Animal Physiology, Saratov State University, Saratov, RussiaIn the brain, the excitation-inhibition balance prevents abnormal synchronous behavior. However, known synaptic conductance intensity can be insufficient to account for the undesired synchronization. Due to this fact, we consider time delay in excitatory and inhibitory conductances and study its effect on the neuronal synchronization. In this work, we build a neuronal network composed of adaptive integrate-and-fire neurons coupled by means of delayed conductances. We observe that the time delay in the excitatory and inhibitory conductivities can alter both the state of the collective behavior (synchronous or desynchronous) and its type (spike or burst). For the weak coupling regime, we find that synchronization appears associated with neurons behaving with extremes highest and lowest mean firing frequency, in contrast to when desynchronization is present when neurons do not exhibit extreme values for the firing frequency. Synchronization can also be characterized by neurons presenting either the highest or the lowest levels in the mean synaptic current. For the strong coupling, synchronous burst activities can occur for delays in the inhibitory conductivity. For approximately equal-length delays in the excitatory and inhibitory conductances, desynchronous spikes activities are identified for both weak and strong coupling regimes. Therefore, our results show that not only the conductance intensity, but also short delays in the inhibitory conductance are relevant to avoid abnormal neuronal synchronization.https://www.frontiersin.org/article/10.3389/fphys.2020.01053/fullsynchronizationintegrate-and-fireneuronal networktime delayconductance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Paulo R. Protachevicz Paulo R. Protachevicz Fernando S. Borges Kelly C. Iarosz Kelly C. Iarosz Kelly C. Iarosz Murilo S. Baptista Ewandson L. Lameu Matheus Hansen Matheus Hansen Iberê L. Caldas José D. Szezech José D. Szezech Antonio M. Batista Antonio M. Batista Antonio M. Batista Jürgen Kurths Jürgen Kurths Jürgen Kurths |
spellingShingle |
Paulo R. Protachevicz Paulo R. Protachevicz Fernando S. Borges Kelly C. Iarosz Kelly C. Iarosz Kelly C. Iarosz Murilo S. Baptista Ewandson L. Lameu Matheus Hansen Matheus Hansen Iberê L. Caldas José D. Szezech José D. Szezech Antonio M. Batista Antonio M. Batista Antonio M. Batista Jürgen Kurths Jürgen Kurths Jürgen Kurths Influence of Delayed Conductance on Neuronal Synchronization Frontiers in Physiology synchronization integrate-and-fire neuronal network time delay conductance |
author_facet |
Paulo R. Protachevicz Paulo R. Protachevicz Fernando S. Borges Kelly C. Iarosz Kelly C. Iarosz Kelly C. Iarosz Murilo S. Baptista Ewandson L. Lameu Matheus Hansen Matheus Hansen Iberê L. Caldas José D. Szezech José D. Szezech Antonio M. Batista Antonio M. Batista Antonio M. Batista Jürgen Kurths Jürgen Kurths Jürgen Kurths |
author_sort |
Paulo R. Protachevicz |
title |
Influence of Delayed Conductance on Neuronal Synchronization |
title_short |
Influence of Delayed Conductance on Neuronal Synchronization |
title_full |
Influence of Delayed Conductance on Neuronal Synchronization |
title_fullStr |
Influence of Delayed Conductance on Neuronal Synchronization |
title_full_unstemmed |
Influence of Delayed Conductance on Neuronal Synchronization |
title_sort |
influence of delayed conductance on neuronal synchronization |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Physiology |
issn |
1664-042X |
publishDate |
2020-09-01 |
description |
In the brain, the excitation-inhibition balance prevents abnormal synchronous behavior. However, known synaptic conductance intensity can be insufficient to account for the undesired synchronization. Due to this fact, we consider time delay in excitatory and inhibitory conductances and study its effect on the neuronal synchronization. In this work, we build a neuronal network composed of adaptive integrate-and-fire neurons coupled by means of delayed conductances. We observe that the time delay in the excitatory and inhibitory conductivities can alter both the state of the collective behavior (synchronous or desynchronous) and its type (spike or burst). For the weak coupling regime, we find that synchronization appears associated with neurons behaving with extremes highest and lowest mean firing frequency, in contrast to when desynchronization is present when neurons do not exhibit extreme values for the firing frequency. Synchronization can also be characterized by neurons presenting either the highest or the lowest levels in the mean synaptic current. For the strong coupling, synchronous burst activities can occur for delays in the inhibitory conductivity. For approximately equal-length delays in the excitatory and inhibitory conductances, desynchronous spikes activities are identified for both weak and strong coupling regimes. Therefore, our results show that not only the conductance intensity, but also short delays in the inhibitory conductance are relevant to avoid abnormal neuronal synchronization. |
topic |
synchronization integrate-and-fire neuronal network time delay conductance |
url |
https://www.frontiersin.org/article/10.3389/fphys.2020.01053/full |
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