Drug-drug interactions of tacrolimus

• Main Authors: Rančić Nemanja K., Vavić Neven N., Kovačević Aleksandra M., Mikov Momir M., Dragojević-Simić Viktorija M.
• Format: Article
• Language: English
• Published: Srpsko lekarsko drustvo 2015-01-01
• Series: Hospital Pharmacology
• Subjects: tacrolimus; P-glycoprotein; CYP3A enzymes; drug-drug interactions
• Online Access: http://scindeks-clanci.ceon.rs/data/pdf/2334-9492/2015/2334-94921503291R.pdf

Introduction: Tacrolimus, potent immunosupressive drug, has large inter- and intraindividual pharmacokinetic variability. The aim: The aim of this current topic is to describe the importance of tacrolimus drug-drug interactions. Pharmacokinetic interactions between tacrolimus and other drugs: Concerning the fact that it is also a medicine with the narrow therapeutic range, its interactions with other drugs mediated by both P-glycoprotein and CYP3A enzymes are potentially very important. Conclusion: Interactions between tacrolimus and other drugs leading to overexposure to tacrolimus is connected with significant toxicity, while the subtherapeutic blood concentrations increase the probability of transplanted organ rejection.