Recent advances in liver transplantation for cancer: The future of transplant oncology

Recent advances in liver transplantation for cancer: The future of transplant oncology

Summary: Liver transplantation is widely indicated as a curative treatment for selected patients with hepatocellular carcinoma. However, with recent therapeutic advances, as well as efforts to increase the donor pool, liver transplantation has been carefully expanded to patients with other primary o...

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Main Authors: Phillipe Abreu, Andre Gorgen, Graziano Oldani, Taizo Hibi, Gonzalo Sapisochin
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:JHEP Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555919300825
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spelling doaj-996c84503cbf443dacc057383e3005482020-11-25T01:15:24ZengElsevierJHEP Reports2589-55592019-11-0115377391Recent advances in liver transplantation for cancer: The future of transplant oncologyPhillipe Abreu0Andre Gorgen1Graziano Oldani2Taizo Hibi3Gonzalo Sapisochin4Multi-Organ Transplant Program, Division of General Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, CanadaMulti-Organ Transplant Program, Division of General Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, CanadaMulti-Organ Transplant Program, Division of General Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, CanadaDepartment of Pediatric Surgery and Transplantation, Kumamoto University Graduate School of Medical Sciences, Kumamoto, JapanMulti-Organ Transplant Program, Division of General Surgery, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada; Corresponding author. Address: HBP & Multi Organ Transplant Program, Division of General Surgery. University Health Network, University of Toronto, 585 University Avenue, 11PMB184, Toronto, M5G 2N2, ON, Canada; Tel.: +1 416 340 4800x5169; fax: +1 416 340 3237.Summary: Liver transplantation is widely indicated as a curative treatment for selected patients with hepatocellular carcinoma. However, with recent therapeutic advances, as well as efforts to increase the donor pool, liver transplantation has been carefully expanded to patients with other primary or secondary malignancies in the liver. Cholangiocarcinoma, colorectal and neuroendocrine liver metastases, and hepatic epithelioid haemangioendothelioma are amongst the most relevant new indications. In this review we discuss the fundamental concepts of this ambitious undertaking, as well as the newest indications for liver transplantation, with a special focus on future perspectives within the recently established concept of transplant oncology. Keywords: Liver transplant, Oncology, Hepatocellular Carcinoma, Cholangiocarcinoma, Colorectal Liver Metastasis, Neuroendocrine Tumours, Hepatic Epithelioid Hemangioendotheliomahttp://www.sciencedirect.com/science/article/pii/S2589555919300825
collection DOAJ
language English
format Article
sources DOAJ
author Phillipe Abreu
Andre Gorgen
Graziano Oldani
Taizo Hibi
Gonzalo Sapisochin
spellingShingle Phillipe Abreu
Andre Gorgen
Graziano Oldani
Taizo Hibi
Gonzalo Sapisochin
Recent advances in liver transplantation for cancer: The future of transplant oncology
JHEP Reports
author_facet Phillipe Abreu
Andre Gorgen
Graziano Oldani
Taizo Hibi
Gonzalo Sapisochin
author_sort Phillipe Abreu
title Recent advances in liver transplantation for cancer: The future of transplant oncology
title_short Recent advances in liver transplantation for cancer: The future of transplant oncology
title_full Recent advances in liver transplantation for cancer: The future of transplant oncology
title_fullStr Recent advances in liver transplantation for cancer: The future of transplant oncology
title_full_unstemmed Recent advances in liver transplantation for cancer: The future of transplant oncology
title_sort recent advances in liver transplantation for cancer: the future of transplant oncology
publisher Elsevier
series JHEP Reports
issn 2589-5559
publishDate 2019-11-01
description Summary: Liver transplantation is widely indicated as a curative treatment for selected patients with hepatocellular carcinoma. However, with recent therapeutic advances, as well as efforts to increase the donor pool, liver transplantation has been carefully expanded to patients with other primary or secondary malignancies in the liver. Cholangiocarcinoma, colorectal and neuroendocrine liver metastases, and hepatic epithelioid haemangioendothelioma are amongst the most relevant new indications. In this review we discuss the fundamental concepts of this ambitious undertaking, as well as the newest indications for liver transplantation, with a special focus on future perspectives within the recently established concept of transplant oncology. Keywords: Liver transplant, Oncology, Hepatocellular Carcinoma, Cholangiocarcinoma, Colorectal Liver Metastasis, Neuroendocrine Tumours, Hepatic Epithelioid Hemangioendothelioma
url http://www.sciencedirect.com/science/article/pii/S2589555919300825
work_keys_str_mv AT phillipeabreu recentadvancesinlivertransplantationforcancerthefutureoftransplantoncology
AT andregorgen recentadvancesinlivertransplantationforcancerthefutureoftransplantoncology
AT grazianooldani recentadvancesinlivertransplantationforcancerthefutureoftransplantoncology
AT taizohibi recentadvancesinlivertransplantationforcancerthefutureoftransplantoncology
AT gonzalosapisochin recentadvancesinlivertransplantationforcancerthefutureoftransplantoncology
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