An efficient crossover design for thorough QT studies / Ein effizientes Crossover-Design für klinische Studien zur Untersuchung des QT-Intervalls

An efficient crossover design for thorough QT studies / Ein effizientes Crossover-Design für klinische Studien zur Untersuchung des QT-Intervalls

Background: Thorough QT studies are typically a requirement of the clinical development program for new investigational drugs. These studies are a major cost factor in early development. The objectives of a typical thorough QT study (TQT) are to demonstrate (a) that therapeutic and supra-therapeutic...

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Bibliographic Details
Main Authors: Ring, Arne, Walter, Beate, Larbalestier, Anna, Chanter, Dennis
Format: Article
Language:deu
Published: German Medical Science GMS Publishing House 2010-01-01
Series:GMS Medizinische Informatik, Biometrie und Epidemiologie
Subjects:
thorough QT study
Williams design
orthogonal Latin squares
statistical efficiency
permutations
group theory
Online Access:http://www.egms.de/en/journals/mibe/2010-6/mibe000105.shtml

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