The Therapeutic Potential of the Labdane Diterpenoid Forskolin

The Therapeutic Potential of the Labdane Diterpenoid Forskolin

Forskolin is mainly found in the root of a plant called <i>Coleus forskohlii</i> (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskoli...

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Main Authors: Bahare Salehi, Mariola Staniak, Katarzyna Czopek, Anna Stępień, Kamal Dua, Ridhima Wadhwa, Dinesh Kumar Chellappan, Oksana Sytar, Marian Brestic, Namrata Ganesh Bhat, Nanjangud Venkatesh Anil Kumar, María del Mar Contreras, Farukh Sharopov, William C. Cho, Javad Sharifi-Rad
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Applied Sciences
Subjects:
forskolin
plant secondary metabolites
<i>coleus forskohlii</i>
camp pathway
Online Access:https://www.mdpi.com/2076-3417/9/19/4089
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spelling doaj-9983aaad4fee42acbde3b06bcd44953b2020-11-24T21:51:05ZengMDPI AGApplied Sciences2076-34172019-09-01919408910.3390/app9194089app9194089The Therapeutic Potential of the Labdane Diterpenoid ForskolinBahare Salehi0Mariola Staniak1Katarzyna Czopek2Anna Stępień3Kamal Dua4Ridhima Wadhwa5Dinesh Kumar Chellappan6Oksana Sytar7Marian Brestic8Namrata Ganesh Bhat9Nanjangud Venkatesh Anil Kumar10María del Mar Contreras11Farukh Sharopov12William C. Cho13Javad Sharifi-Rad14Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, IranInstitute of Soil Science and Plant Cultivation—State Research Institute, Czartoryskich Str. 8, 24-100 Puławy, PolandInstitute of Soil Science and Plant Cultivation—State Research Institute, Czartoryskich Str. 8, 24-100 Puławy, PolandInstitute of Soil Science and Plant Cultivation—State Research Institute, Czartoryskich Str. 8, 24-100 Puławy, PolandDiscipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, NSW 2007, AustraliaFaculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi 110021, IndiaDepartment of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, MalaysiaDepartment of Plant Biology Department, Taras Shevchenko National University of Kyiv, Institute of Biology, Volodymyrska str., 64, Kyiv 01033, UkraineDepartment of Plant Physiology, Slovak University of Agriculture, Nitra, A. Hlinku 2, 94976 Nitra, SlovakDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Chemistry, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal 576104, IndiaDepartment of Chemical, Environmental and Materials Engineering, University of Jaén, 23071 Jaén, SpainDepartment of Pharmaceutical Technology, Avicenna Tajik State Medical University, Dushanbe 73400, TajikistanDepartment of Clinical Oncology, Queen Elizabeth Hospital, 30 Gascoigne Road, Hong Kong, ChinaDepartment of Pharmacology, Faculty of Medicine, Jiroft University of Medical Sciences, Jiroft 7861756447, IranForskolin is mainly found in the root of a plant called <i>Coleus forskohlii</i> (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.https://www.mdpi.com/2076-3417/9/19/4089forskolinplant secondary metabolites<i>coleus forskohlii</i>camp pathway
collection DOAJ
language English
format Article
sources DOAJ
author Bahare Salehi
Mariola Staniak
Katarzyna Czopek
Anna Stępień
Kamal Dua
Ridhima Wadhwa
Dinesh Kumar Chellappan
Oksana Sytar
Marian Brestic
Namrata Ganesh Bhat
Nanjangud Venkatesh Anil Kumar
María del Mar Contreras
Farukh Sharopov
William C. Cho
Javad Sharifi-Rad
spellingShingle Bahare Salehi
Mariola Staniak
Katarzyna Czopek
Anna Stępień
Kamal Dua
Ridhima Wadhwa
Dinesh Kumar Chellappan
Oksana Sytar
Marian Brestic
Namrata Ganesh Bhat
Nanjangud Venkatesh Anil Kumar
María del Mar Contreras
Farukh Sharopov
William C. Cho
Javad Sharifi-Rad
The Therapeutic Potential of the Labdane Diterpenoid Forskolin
Applied Sciences
forskolin
plant secondary metabolites
<i>coleus forskohlii</i>
camp pathway
author_facet Bahare Salehi
Mariola Staniak
Katarzyna Czopek
Anna Stępień
Kamal Dua
Ridhima Wadhwa
Dinesh Kumar Chellappan
Oksana Sytar
Marian Brestic
Namrata Ganesh Bhat
Nanjangud Venkatesh Anil Kumar
María del Mar Contreras
Farukh Sharopov
William C. Cho
Javad Sharifi-Rad
author_sort Bahare Salehi
title The Therapeutic Potential of the Labdane Diterpenoid Forskolin
title_short The Therapeutic Potential of the Labdane Diterpenoid Forskolin
title_full The Therapeutic Potential of the Labdane Diterpenoid Forskolin
title_fullStr The Therapeutic Potential of the Labdane Diterpenoid Forskolin
title_full_unstemmed The Therapeutic Potential of the Labdane Diterpenoid Forskolin
title_sort therapeutic potential of the labdane diterpenoid forskolin
publisher MDPI AG
series Applied Sciences
issn 2076-3417
publishDate 2019-09-01
description Forskolin is mainly found in the root of a plant called <i>Coleus forskohlii</i> (Willd.) Briq., which has been used in the traditional medicine of Indian Ayurvedic and Southeast Asia since ancient times. Forskolin is responsible for the pharmacological activity of this species. Forskolin is a labdane diterpenoid with a wide biological effect. Several studies suggested a positive role of forskolin on heart complications, respiratory disorders, high blood pressure, obesity, and asthma. There are numerous clinical and pre-clinical studies representing the effect of forskolin on the above-mentioned disorders but more clinical studies need to be performed to support its efficacy.
topic forskolin
plant secondary metabolites
<i>coleus forskohlii</i>
camp pathway
url https://www.mdpi.com/2076-3417/9/19/4089
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