Novel 1-Amidino-4-Phenylpiperazines as Potent Agonists at Human TAAR1 Receptor: Rational Design, Synthesis, Biological Evaluation and Molecular Docking Studies

Novel 1-Amidino-4-Phenylpiperazines as Potent Agonists at Human TAAR1 Receptor: Rational Design, Synthesis, Biological Evaluation and Molecular Docking Studies

Targeting trace amine-associated receptor 1 (TAAR1) receptor continues to offer an intriguing opportunity to develop innovative therapies in different pharmacological settings. Pursuing our endeavors in the search for effective and safe human TAAR1 (<i>h</i>TAAR1) ligands, we synthesized...

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Bibliographic Details
Main Authors: Valeria Francesconi, Elena Cichero, Evgeny V. Kanov, Erik Laurini, Sabrina Pricl, Raul R. Gainetdinov, Michele Tonelli
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Pharmaceuticals
Subjects:
trace amine-associated receptor 1 (TAAR1)
human TAAR1 agonists
1-amidino-4-phenylpiperazines
pharmacophore model
docking studies
Online Access:https://www.mdpi.com/1424-8247/13/11/391

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