Modulation of mTORC1 Signaling Pathway by HIV-1

Modulation of mTORC1 Signaling Pathway by HIV-1

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely...

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Bibliographic Details
Main Authors: Burkitkan Akbay, Anna Shmakova, Yegor Vassetzky, Svetlana Dokudovskaya
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
HIV-1
HIV-1 related diseases
mTORC1 pathway
autophagy
Online Access:https://www.mdpi.com/2073-4409/9/5/1090
Description
Summary:Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.
ISSN:2073-4409

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