Modulation of mTORC1 Signaling Pathway by HIV-1

Modulation of mTORC1 Signaling Pathway by HIV-1

Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely...

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Main Authors: Burkitkan Akbay, Anna Shmakova, Yegor Vassetzky, Svetlana Dokudovskaya
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
HIV-1
HIV-1 related diseases
mTORC1 pathway
autophagy
Online Access:https://www.mdpi.com/2073-4409/9/5/1090
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spelling doaj-9985c6f625604149bd201a5516761d542020-11-25T03:05:17ZengMDPI AGCells2073-44092020-04-0191090109010.3390/cells9051090Modulation of mTORC1 Signaling Pathway by HIV-1Burkitkan Akbay0Anna Shmakova1Yegor Vassetzky2Svetlana Dokudovskaya3CNRS UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 114, rue Édouard Vaillant, 94805 Villejuif, FranceCNRS UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 114, rue Édouard Vaillant, 94805 Villejuif, FranceCNRS UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 114, rue Édouard Vaillant, 94805 Villejuif, FranceCNRS UMR 9018, Institut Gustave Roussy, Université Paris-Saclay, 114, rue Édouard Vaillant, 94805 Villejuif, FranceMammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.https://www.mdpi.com/2073-4409/9/5/1090HIV-1HIV-1 related diseasesmTORC1 pathwayautophagy
collection DOAJ
language English
format Article
sources DOAJ
author Burkitkan Akbay
Anna Shmakova
Yegor Vassetzky
Svetlana Dokudovskaya
spellingShingle Burkitkan Akbay
Anna Shmakova
Yegor Vassetzky
Svetlana Dokudovskaya
Modulation of mTORC1 Signaling Pathway by HIV-1
Cells
HIV-1
HIV-1 related diseases
mTORC1 pathway
autophagy
author_facet Burkitkan Akbay
Anna Shmakova
Yegor Vassetzky
Svetlana Dokudovskaya
author_sort Burkitkan Akbay
title Modulation of mTORC1 Signaling Pathway by HIV-1
title_short Modulation of mTORC1 Signaling Pathway by HIV-1
title_full Modulation of mTORC1 Signaling Pathway by HIV-1
title_fullStr Modulation of mTORC1 Signaling Pathway by HIV-1
title_full_unstemmed Modulation of mTORC1 Signaling Pathway by HIV-1
title_sort modulation of mtorc1 signaling pathway by hiv-1
publisher MDPI AG
series Cells
issn 2073-4409
publishDate 2020-04-01
description Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of cellular proliferation and survival which controls cellular response to different stresses, including viral infection. HIV-1 interferes with the mTORC1 pathway at every stage of infection. At the same time, the host cells rely on the mTORC1 pathway and autophagy to fight against virus replication and transmission. In this review, we will provide the most up-to-date picture of the role of the mTORC1 pathway in the HIV-1 life cycle, latency and HIV-related diseases. We will also provide an overview of recent trends in the targeting of the mTORC1 pathway as a promising strategy for HIV-1 eradication.
topic HIV-1
HIV-1 related diseases
mTORC1 pathway
autophagy
url https://www.mdpi.com/2073-4409/9/5/1090
work_keys_str_mv AT burkitkanakbay modulationofmtorc1signalingpathwaybyhiv1
AT annashmakova modulationofmtorc1signalingpathwaybyhiv1
AT yegorvassetzky modulationofmtorc1signalingpathwaybyhiv1
AT svetlanadokudovskaya modulationofmtorc1signalingpathwaybyhiv1
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