Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women
Abstract Background The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the associations of body fatness with the risk of breast cancer varied with pho...
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doaj-998df8435a9742a3bb4e7e2d04cc07c92021-08-01T11:10:54ZengBMCBreast Cancer Research1465-542X2021-07-0123111110.1186/s13058-021-01458-zBody fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black womenTing-Yuan David Cheng0Angela R. Omilian1Song Yao2Weizhou Zhang3Susmita Datta4Wiam Bshara5Rochelle Payne Ondracek6Warren Davis7Song Liu8Chi-Chen Hong9Elisa V. Bandera10Thaer Khoury11Christine B. Ambrosone12Department of Epidemiology, University of FloridaDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterDepartment of Pathology, Immunology and Laboratory Medicine, University of FloridaDepartment of Biostatistics, University of FloridaDepartment of Pathology & Laboratory Medicine, Roswell Park Comprehensive Cancer CenterDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterDepartment of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer CenterDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterCancer Epidemiology and Health Outcomes, Rutgers Cancer Institute of New Jersey, The State University of New JerseyDepartment of Pathology & Laboratory Medicine, Roswell Park Comprehensive Cancer CenterDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer CenterAbstract Background The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the associations of body fatness with the risk of breast cancer varied with phosphorylated (p)-mTOR protein expression, an indication of the pathway activation. Methods Women with newly diagnosed breast cancer (n = 715; 574 [80%] Black and 141 [20%] White) and non-cancer controls (n = 1983; 1280 [64%] Black and 713 [36%] White) were selected from the Women’s Circle of Health Study. Surgical tumor samples among the cases were immunostained for p-mTOR (Ser2448) and classified as p-mTOR-overexpressed, if the expression level ≥ 75th percentile, or p-mTOR-negative/low otherwise. Anthropometrics were measured by trained staff, and body composition was determined by bioelectrical impedance analysis. Odds ratios (ORs) of p-mTOR-overexpressed tumors and p-mTOR-negative/low tumors compared to controls were estimated using polytomous logistic regression. The differences in the associations by the p-mTOR expression status were assessed by tests for heterogeneity. Results Cases with p-mTOR-overexpressed tumors, but not cases with p-mTOR-negative/low tumors, compared to controls were more likely to have higher body mass index (BMI), percent body fat, and fat mass index (P-heterogeneity < 0.05), although the OR estimates were not significant. For the measurement of central adiposity, cases with p-mTOR overexpressed tumors had a higher odds of being at the Q3 (OR = 2.52, 95% CI = 1.46 to 4.34) and Q4 (OR = 1.99, 95% CI = 1.12 to 3.50) of waist circumference (WC) compared to controls. Similarly, cases with p-mTOR overexpressed tumors had a higher odds of being at the Q3 (OR = 1.82, 95% CI = 1.11 to 2.98) and Q4 (OR = 1.81, 95% CI = 1.11 to 2.98) of WHR compared to controls. These associations of WC and waist-to-hip ratio (WHR) did not differ by tumor p-mTOR status (P-heterogeneity = 0.27 and 0.48, respectively). Conclusions Our findings suggest that in this population composed of predominately Black women, body fatness is associated with breast cancer differently for p-mTOR overexpression and p-mTOR negative/low expression. Whether mTOR plays a role in the obesity and breast cancer association warrants confirmation by prospective studies.https://doi.org/10.1186/s13058-021-01458-zBreast cancerMechanistic target of rapamycinAfrican American/Black womenBody fatnessCase-control study |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ting-Yuan David Cheng Angela R. Omilian Song Yao Weizhou Zhang Susmita Datta Wiam Bshara Rochelle Payne Ondracek Warren Davis Song Liu Chi-Chen Hong Elisa V. Bandera Thaer Khoury Christine B. Ambrosone |
spellingShingle |
Ting-Yuan David Cheng Angela R. Omilian Song Yao Weizhou Zhang Susmita Datta Wiam Bshara Rochelle Payne Ondracek Warren Davis Song Liu Chi-Chen Hong Elisa V. Bandera Thaer Khoury Christine B. Ambrosone Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women Breast Cancer Research Breast cancer Mechanistic target of rapamycin African American/Black women Body fatness Case-control study |
author_facet |
Ting-Yuan David Cheng Angela R. Omilian Song Yao Weizhou Zhang Susmita Datta Wiam Bshara Rochelle Payne Ondracek Warren Davis Song Liu Chi-Chen Hong Elisa V. Bandera Thaer Khoury Christine B. Ambrosone |
author_sort |
Ting-Yuan David Cheng |
title |
Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women |
title_short |
Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women |
title_full |
Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women |
title_fullStr |
Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women |
title_full_unstemmed |
Body fatness and breast cancer risk in relation to phosphorylated mTOR expression in a sample of predominately Black women |
title_sort |
body fatness and breast cancer risk in relation to phosphorylated mtor expression in a sample of predominately black women |
publisher |
BMC |
series |
Breast Cancer Research |
issn |
1465-542X |
publishDate |
2021-07-01 |
description |
Abstract Background The mechanistic target of rapamycin (mTOR) pathway promoted by positive energy imbalance and insulin-like growth factors can be a mechanism by which obesity influences breast cancer risk. We evaluated the associations of body fatness with the risk of breast cancer varied with phosphorylated (p)-mTOR protein expression, an indication of the pathway activation. Methods Women with newly diagnosed breast cancer (n = 715; 574 [80%] Black and 141 [20%] White) and non-cancer controls (n = 1983; 1280 [64%] Black and 713 [36%] White) were selected from the Women’s Circle of Health Study. Surgical tumor samples among the cases were immunostained for p-mTOR (Ser2448) and classified as p-mTOR-overexpressed, if the expression level ≥ 75th percentile, or p-mTOR-negative/low otherwise. Anthropometrics were measured by trained staff, and body composition was determined by bioelectrical impedance analysis. Odds ratios (ORs) of p-mTOR-overexpressed tumors and p-mTOR-negative/low tumors compared to controls were estimated using polytomous logistic regression. The differences in the associations by the p-mTOR expression status were assessed by tests for heterogeneity. Results Cases with p-mTOR-overexpressed tumors, but not cases with p-mTOR-negative/low tumors, compared to controls were more likely to have higher body mass index (BMI), percent body fat, and fat mass index (P-heterogeneity < 0.05), although the OR estimates were not significant. For the measurement of central adiposity, cases with p-mTOR overexpressed tumors had a higher odds of being at the Q3 (OR = 2.52, 95% CI = 1.46 to 4.34) and Q4 (OR = 1.99, 95% CI = 1.12 to 3.50) of waist circumference (WC) compared to controls. Similarly, cases with p-mTOR overexpressed tumors had a higher odds of being at the Q3 (OR = 1.82, 95% CI = 1.11 to 2.98) and Q4 (OR = 1.81, 95% CI = 1.11 to 2.98) of WHR compared to controls. These associations of WC and waist-to-hip ratio (WHR) did not differ by tumor p-mTOR status (P-heterogeneity = 0.27 and 0.48, respectively). Conclusions Our findings suggest that in this population composed of predominately Black women, body fatness is associated with breast cancer differently for p-mTOR overexpression and p-mTOR negative/low expression. Whether mTOR plays a role in the obesity and breast cancer association warrants confirmation by prospective studies. |
topic |
Breast cancer Mechanistic target of rapamycin African American/Black women Body fatness Case-control study |
url |
https://doi.org/10.1186/s13058-021-01458-z |
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