100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats
Preemptive analgesia involves introducing an analgesic before noxious stimulation. Electroacupuncture (EA) activates descending mechanisms that modulate nociceptive inputs into the spinal dorsal horn. This study evaluated whether preoperative EA is more effective than postoperative EA in reducing in...
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doaj-9999dc7c93c140c5921fd692c3627f5f2021-04-02T05:07:42ZengMedical Association of Pharmacopuncture InstituteJournal of Acupuncture & Meridian Studies2005-29012016-08-019420020610.1016/j.jams.2016.04.006100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in RatsMarcelo Lourenço Silva0Josie Resende Torres Silva1Wiliam Alves Prado2Department of Physiotherapy, College of Nursing of the Federal University of Alfenas—UNIFAL, Alfenas, BrazilDepartment of Physiotherapy, College of Nursing of the Federal University of Alfenas—UNIFAL, Alfenas, BrazilDepartment of Pharmacology, Ribeirão Preto Medical School—University of São Paulo, Ribeirão Preto, BrazilPreemptive analgesia involves introducing an analgesic before noxious stimulation. Electroacupuncture (EA) activates descending mechanisms that modulate nociceptive inputs into the spinal dorsal horn. This study evaluated whether preoperative EA is more effective than postoperative EA in reducing incision pain in rats. The nociceptive threshold to mechanical stimulation was utilized to examine the effects of an intraperitoneal injection of saline (0.1 mL/kg) or naloxone (1 mg/kg) on antinociception induced by a 20-minute period of 2-Hz or 100-Hz EA applied to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints before surgical incision, or 10 minutes after or 100 minutes after surgical incision of the hind paw. The extent of mechanical hyperalgesia after the incision was significantly attenuated by the application of 100-Hz EA preoperatively, but not by its application at 10 minutes or 100 minutes postoperatively. By contrast, 2-Hz EA was effective against postoperative hyperalgesia when applied 10 minutes or 100 minutes after surgery but not when it was applied preoperatively. Only the effect of 2-Hz EA applied 10 minutes after surgery was sensitive to naloxone. The present study showed for the first time that 100-Hz EA, but not 2-Hz EA, exerts a nonopioidergic preemptive effect against postincision pain in rats.http://www.sciencedirect.com/science/article/pii/S2005290116300735electroacupunctureincision painnaloxonepreemptive analgesia |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marcelo Lourenço Silva Josie Resende Torres Silva Wiliam Alves Prado |
spellingShingle |
Marcelo Lourenço Silva Josie Resende Torres Silva Wiliam Alves Prado 100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats Journal of Acupuncture & Meridian Studies electroacupuncture incision pain naloxone preemptive analgesia |
author_facet |
Marcelo Lourenço Silva Josie Resende Torres Silva Wiliam Alves Prado |
author_sort |
Marcelo Lourenço Silva |
title |
100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats |
title_short |
100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats |
title_full |
100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats |
title_fullStr |
100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats |
title_full_unstemmed |
100-Hz Electroacupuncture but not 2-Hz Electroacupuncture is Preemptive Against Postincision Pain in Rats |
title_sort |
100-hz electroacupuncture but not 2-hz electroacupuncture is preemptive against postincision pain in rats |
publisher |
Medical Association of Pharmacopuncture Institute |
series |
Journal of Acupuncture & Meridian Studies |
issn |
2005-2901 |
publishDate |
2016-08-01 |
description |
Preemptive analgesia involves introducing an analgesic before noxious stimulation. Electroacupuncture (EA) activates descending mechanisms that modulate nociceptive inputs into the spinal dorsal horn. This study evaluated whether preoperative EA is more effective than postoperative EA in reducing incision pain in rats. The nociceptive threshold to mechanical stimulation was utilized to examine the effects of an intraperitoneal injection of saline (0.1 mL/kg) or naloxone (1 mg/kg) on antinociception induced by a 20-minute period of 2-Hz or 100-Hz EA applied to the Zusanli (ST36) and Sanyinjiao (SP6) acupoints before surgical incision, or 10 minutes after or 100 minutes after surgical incision of the hind paw. The extent of mechanical hyperalgesia after the incision was significantly attenuated by the application of 100-Hz EA preoperatively, but not by its application at 10 minutes or 100 minutes postoperatively. By contrast, 2-Hz EA was effective against postoperative hyperalgesia when applied 10 minutes or 100 minutes after surgery but not when it was applied preoperatively. Only the effect of 2-Hz EA applied 10 minutes after surgery was sensitive to naloxone. The present study showed for the first time that 100-Hz EA, but not 2-Hz EA, exerts a nonopioidergic preemptive effect against postincision pain in rats. |
topic |
electroacupuncture incision pain naloxone preemptive analgesia |
url |
http://www.sciencedirect.com/science/article/pii/S2005290116300735 |
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