Influence of Splitting on Dissolution Properties of Metoprolol Tablets

• Main Authors: Edina Vranić, Alija Uzunović
• Format: Article
• Language: English
• Published: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2009-08-01
• Series: Bosnian Journal of Basic Medical Sciences
• Subjects: metoprolol; extended release; tablet splitting; dissolution profile
• Online Access: http://www.bjbms.org/ojs/index.php/bjbms/article/view/2815

The objective of this work was to compare several profiles of dissolution data for metoprolol controlled release tablet formulations in order to identify possible changes in dissolution profiles of whole and scored tablets. Adequate design of score lines (on one or both sides) as well as the technology of preparation of tablet mixtures ensure forming a score line of adequate thickness, shape, size, curvature. According to the obtained results, this type of extended release formulation is eligible for splitting and use in therapy either as a whole or scored tablets.