Heterologous Biosynthesis, Modifications and Structural Characterization of Ruminococcin-A, a Lanthipeptide From the Gut Bacterium Ruminococcus gnavus E1, in Escherichia coli
Ruminococcin A (RumA) is a lanthipeptide with high activity against pathogenic clostridia and is naturally produced by the strict anaerobic bacterium Ruminococcus gnavus E1, isolated from human intestine. Cultivating R. gnavus E1 is challenging, limiting high-quality production, further biotechnolog...
Main Authors: | Elvis L. Ongey, Robert T. Giessmann, Michel Fons, Juri Rappsilber, Lorenz Adrian, Peter Neubauer |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2018-07-01
|
Series: | Frontiers in Microbiology |
Subjects: | |
Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.01688/full |
Similar Items
-
Bioprocess Development for Lantibiotic Ruminococcin-A Production in Escherichia coli and Kinetic Insights Into LanM Enzymes Catalysis
by: Elvis L. Ongey, et al.
Published: (2019-09-01) -
A Cell‐Free Platform Based on Nisin Biosynthesis for Discovering Novel Lanthipeptides and Guiding their Overproduction In Vivo
by: Ran Liu, et al.
Published: (2020-09-01) -
Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms
by: Caiyun Li, et al.
Published: (2021-07-01) -
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
by: Mark C. Walker, et al.
Published: (2020-06-01) -
Identification of Putative Novel Class-I Lanthipeptides in Firmicutes: A Combinatorial In Silico Analysis Approach Performed on Genome Sequenced Bacteria and a Close Inspection of Z-Geobacillin Lanthipeptide Biosynthesis Gene Cluster of the Thermophilic Geobacillus sp. Strain ZGt-1
by: Rawana N. Alkhalili, et al.
Published: (2018-09-01)