Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory
Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been establishe...
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doaj-99a10b660a66488995e73f6675ac6ddd2020-11-25T02:56:29ZengBMCCancer Cell International1475-28672020-03-0120111010.1186/s12935-020-1147-9Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theoryWenhao Luo0Gang Yang1Wentao Luo2Zhe Cao3Yueze Liu4Jiangdong Qiu5Guangyu Chen6Lei You7Fangyu Zhao8Lianfang Zheng9Taiping Zhang10Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Mechanical Engineering, Tsinghua UniversityDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeDepartment of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical CollegeAbstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer.http://link.springer.com/article/10.1186/s12935-020-1147-9VaccinationPancreatic cancerMetastasisImmune therapyNovel strategies |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wenhao Luo Gang Yang Wentao Luo Zhe Cao Yueze Liu Jiangdong Qiu Guangyu Chen Lei You Fangyu Zhao Lianfang Zheng Taiping Zhang |
spellingShingle |
Wenhao Luo Gang Yang Wentao Luo Zhe Cao Yueze Liu Jiangdong Qiu Guangyu Chen Lei You Fangyu Zhao Lianfang Zheng Taiping Zhang Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory Cancer Cell International Vaccination Pancreatic cancer Metastasis Immune therapy Novel strategies |
author_facet |
Wenhao Luo Gang Yang Wentao Luo Zhe Cao Yueze Liu Jiangdong Qiu Guangyu Chen Lei You Fangyu Zhao Lianfang Zheng Taiping Zhang |
author_sort |
Wenhao Luo |
title |
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
title_short |
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
title_full |
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
title_fullStr |
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
title_full_unstemmed |
Novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
title_sort |
novel therapeutic strategies and perspectives for metastatic pancreatic cancer: vaccine therapy is more than just a theory |
publisher |
BMC |
series |
Cancer Cell International |
issn |
1475-2867 |
publishDate |
2020-03-01 |
description |
Abstract Pancreatic cancer is an aggressive and malignant tumor with an exceedingly high mortality rate. The quality of life and survival rates of pancreatic cancer patients with metastasis are poor compared with those without metastasis. Thus far, no effective treatment strategy has been established for metastatic pancreatic cancer patients. Therefore, an appropriate therapeutic method based on the elimination of metastatic pancreatic cancer is critical to improve patient outcome. Tumor-targeted vaccines have been widely discussed in recent studies and enabled important breakthroughs in the treatment of pancreatic cancer by preventing the escape of tumor cells from immune surveillance and activating the immune system to eliminate cancer cells. T cells can be activated by the stimulation of tumor-targeted vaccines, but to mount an effective immune response, both immune checkpoint inhibitors and positive costimulatory molecules are required. In this review, we discuss potential tumor-targeted vaccines that can target pancreatic cancer, elaborate the probably appropriate combination of vaccines therapy and evaluate the underlying benefits as well as obstacles in the current therapy for metastatic pancreatic cancer. |
topic |
Vaccination Pancreatic cancer Metastasis Immune therapy Novel strategies |
url |
http://link.springer.com/article/10.1186/s12935-020-1147-9 |
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