Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction

Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction

Abstract Background Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in the metastatic process remains unclear. In addition, potential bleeding...

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Bibliographic Details
Main Authors: Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu, Xin Liang
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Journal of Hematology & Oncology
Subjects:
GPIbα
vWF
Platelets
Antibody
Metastasis
Online Access:http://link.springer.com/article/10.1186/s13045-018-0659-4

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