Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease.
BACKGROUND:A low serum total bilirubin (T-bil) level is associated with an increased risk of atherosclerosis. However, the differential impact of the serum T-bil level on cerebral atherosclerosis and cerebral small vessel disease (SVD) is still unclear. METHODS:We evaluated serum T-bil levels from 1...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2017-01-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC5358834?pdf=render |
id |
doaj-99a79c916c5e4140a2edebc46a7919e3 |
---|---|
record_format |
Article |
spelling |
doaj-99a79c916c5e4140a2edebc46a7919e32020-11-25T01:36:31ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01123e017373610.1371/journal.pone.0173736Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease.Jonguk KimSeung-Jae YoonMin-Hee WooSang-Heum KimNam-Keun KimJinkwon KimOk-Joon KimSeung-Hun OhBACKGROUND:A low serum total bilirubin (T-bil) level is associated with an increased risk of atherosclerosis. However, the differential impact of the serum T-bil level on cerebral atherosclerosis and cerebral small vessel disease (SVD) is still unclear. METHODS:We evaluated serum T-bil levels from 1,128 neurologically healthy subjects. Indices of cerebral atherosclerosis (extracranial arterial stenosis [ECAS] and intracranial arterial stenosis [ICAS]), and indices of SVD (silent lacunar infarct [SLI], and moderate-to-severe white matter hyperintensities [msWMH]) were evaluated by the use of brain magnetic resonance imaging (MRI) and MR angiography. RESULTS:In logistic regression analysis after adjusting for confounding variables, subjects within middle T-bil (odds ratio [OR]: 0.63; 95% CI: 0.41-0.97) and high T-bil tertiles (OR: 0.54; 95% CI: 0.33-0.86) showed a lower prevalence of ECAS than those in a low T-bil tertile. Although subjects with a high T-bil tertile had a lower prevalence of ICAS than those with a low T-bil tertile, the statistical significance was marginal after adjusting for confounding variables. There were no significant differences in the proportions of subjects with SLI and msWMH across serum T-bil tertile groups. CONCLUSIONS:The serum T-bil level is negatively associated with cerebral atherosclerosis, especially extracranial atherosclerosis, but not with SVD.http://europepmc.org/articles/PMC5358834?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonguk Kim Seung-Jae Yoon Min-Hee Woo Sang-Heum Kim Nam-Keun Kim Jinkwon Kim Ok-Joon Kim Seung-Hun Oh |
spellingShingle |
Jonguk Kim Seung-Jae Yoon Min-Hee Woo Sang-Heum Kim Nam-Keun Kim Jinkwon Kim Ok-Joon Kim Seung-Hun Oh Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. PLoS ONE |
author_facet |
Jonguk Kim Seung-Jae Yoon Min-Hee Woo Sang-Heum Kim Nam-Keun Kim Jinkwon Kim Ok-Joon Kim Seung-Hun Oh |
author_sort |
Jonguk Kim |
title |
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
title_short |
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
title_full |
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
title_fullStr |
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
title_full_unstemmed |
Differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
title_sort |
differential impact of serum total bilirubin level on cerebral atherosclerosis and cerebral small vessel disease. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
BACKGROUND:A low serum total bilirubin (T-bil) level is associated with an increased risk of atherosclerosis. However, the differential impact of the serum T-bil level on cerebral atherosclerosis and cerebral small vessel disease (SVD) is still unclear. METHODS:We evaluated serum T-bil levels from 1,128 neurologically healthy subjects. Indices of cerebral atherosclerosis (extracranial arterial stenosis [ECAS] and intracranial arterial stenosis [ICAS]), and indices of SVD (silent lacunar infarct [SLI], and moderate-to-severe white matter hyperintensities [msWMH]) were evaluated by the use of brain magnetic resonance imaging (MRI) and MR angiography. RESULTS:In logistic regression analysis after adjusting for confounding variables, subjects within middle T-bil (odds ratio [OR]: 0.63; 95% CI: 0.41-0.97) and high T-bil tertiles (OR: 0.54; 95% CI: 0.33-0.86) showed a lower prevalence of ECAS than those in a low T-bil tertile. Although subjects with a high T-bil tertile had a lower prevalence of ICAS than those with a low T-bil tertile, the statistical significance was marginal after adjusting for confounding variables. There were no significant differences in the proportions of subjects with SLI and msWMH across serum T-bil tertile groups. CONCLUSIONS:The serum T-bil level is negatively associated with cerebral atherosclerosis, especially extracranial atherosclerosis, but not with SVD. |
url |
http://europepmc.org/articles/PMC5358834?pdf=render |
work_keys_str_mv |
AT jongukkim differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT seungjaeyoon differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT minheewoo differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT sangheumkim differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT namkeunkim differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT jinkwonkim differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT okjoonkim differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease AT seunghunoh differentialimpactofserumtotalbilirubinleveloncerebralatherosclerosisandcerebralsmallvesseldisease |
_version_ |
1725062590319558656 |