Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata
An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2–6) by spectroscopic methods, including 1D an...
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2012-10-01
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Online Access: | http://www.mdpi.com/1660-3397/10/10/2222 |
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doaj-99ae0441e1e346ddab3fb1913ff5bd712020-11-24T21:37:21ZengMDPI AGMarine Drugs1660-33972012-10-0110102222223310.3390/md10102222Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeataHui-Seong KimDur-Han KwonHwa Jung ChoiJungyeob HamHeejin KimPilju ChoiYoung-Joo KimSeokjoon LeeGab Man ParkTaejung KimWoon-Seob ShinJae-Hyoung SongSoon-Hye ParkAn extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2–6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus.http://www.mdpi.com/1660-3397/10/10/2222Neorhodomela aculeatered algapolybromocatechol compoundsantiviral activityhuman rhinovirus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hui-Seong Kim Dur-Han Kwon Hwa Jung Choi Jungyeob Ham Heejin Kim Pilju Choi Young-Joo Kim Seokjoon Lee Gab Man Park Taejung Kim Woon-Seob Shin Jae-Hyoung Song Soon-Hye Park |
spellingShingle |
Hui-Seong Kim Dur-Han Kwon Hwa Jung Choi Jungyeob Ham Heejin Kim Pilju Choi Young-Joo Kim Seokjoon Lee Gab Man Park Taejung Kim Woon-Seob Shin Jae-Hyoung Song Soon-Hye Park Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata Marine Drugs Neorhodomela aculeate red alga polybromocatechol compounds antiviral activity human rhinovirus |
author_facet |
Hui-Seong Kim Dur-Han Kwon Hwa Jung Choi Jungyeob Ham Heejin Kim Pilju Choi Young-Joo Kim Seokjoon Lee Gab Man Park Taejung Kim Woon-Seob Shin Jae-Hyoung Song Soon-Hye Park |
author_sort |
Hui-Seong Kim |
title |
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata |
title_short |
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata |
title_full |
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata |
title_fullStr |
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata |
title_full_unstemmed |
Anti-Human Rhinoviral Activity of Polybromocatechol Compounds Isolated from the Rhodophyta, Neorhodomela aculeata |
title_sort |
anti-human rhinoviral activity of polybromocatechol compounds isolated from the rhodophyta, neorhodomela aculeata |
publisher |
MDPI AG |
series |
Marine Drugs |
issn |
1660-3397 |
publishDate |
2012-10-01 |
description |
An extract of the red alga, Neorhodomela aculeata, exhibited antiviral activity against human rhinoviruses. Bioassay-guided purification was performed to yield six compounds, which were subsequently identified as lanosol (1) and five polybromocatechols (2–6) by spectroscopic methods, including 1D and 2D NMR and mass spectrometric analyses. Structurally, all of these compounds, except compound 5, contain one or two 2,3-dibromo-4,5-dihydroxyphenyl moieties. In a biological activity assay, compound 1 was found to possess antiviral activity with a 50% inhibitory concentration (IC50) of 2.50 μg/mL against HRV2. Compound 3 showed anti-HRV2 activity, with an IC50 of 7.11 μg/mL, and anti-HRV3 activity, with an IC50 of 4.69 μg/mL, without demonstrable cytotoxicity at a concentration of 20 μg/mL. Collectively, the results suggest that compounds 1 and 3 are candidates for novel therapeutics against two different groups of human rhinovirus. |
topic |
Neorhodomela aculeate red alga polybromocatechol compounds antiviral activity human rhinovirus |
url |
http://www.mdpi.com/1660-3397/10/10/2222 |
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