Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication...

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Bibliographic Details
Main Authors: Olivier Reynard, Xuan-Nhi Nguyen, Nathalie Alazard-Dany, Véronique Barateau, Andrea Cimarelli, Viktor E. Volchkov
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
Ebola
Marburg
Filovirus
polymerase
antiviral
inhibitors
Online Access:http://www.mdpi.com/1999-4915/7/12/2934
Description
Summary:The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.
ISSN:1999-4915

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