Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication

The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication...

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Main Authors: Olivier Reynard, Xuan-Nhi Nguyen, Nathalie Alazard-Dany, Véronique Barateau, Andrea Cimarelli, Viktor E. Volchkov
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
Ebola
Marburg
Filovirus
polymerase
antiviral
inhibitors
Online Access:http://www.mdpi.com/1999-4915/7/12/2934
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spelling doaj-99bce1ea36c24f27b53858bc15110b9b2020-11-24T23:16:50ZengMDPI AGViruses1999-49152015-12-017126233624010.3390/v7122934v7122934Identification of a New Ribonucleoside Inhibitor of Ebola Virus ReplicationOlivier Reynard0Xuan-Nhi Nguyen1Nathalie Alazard-Dany2Véronique Barateau3Andrea Cimarelli4Viktor E. Volchkov5Molecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceHost Pathogen interaction during lentiviral infection, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceMolecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceHost Pathogen interaction during lentiviral infection, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceHost Pathogen interaction during lentiviral infection, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceMolecular Basis of Viral Pathogenicity, CIRI, INSERM, U1111-CNRS UMR5308, Université de Lyon, Université Claude Bernard Lyon 1, Ecole Normale Supérieure de Lyon, Lyon 69007, FranceThe current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.http://www.mdpi.com/1999-4915/7/12/2934EbolaMarburgFiloviruspolymeraseantiviralinhibitors
collection DOAJ
language English
format Article
sources DOAJ
author Olivier Reynard
Xuan-Nhi Nguyen
Nathalie Alazard-Dany
Véronique Barateau
Andrea Cimarelli
Viktor E. Volchkov
spellingShingle Olivier Reynard
Xuan-Nhi Nguyen
Nathalie Alazard-Dany
Véronique Barateau
Andrea Cimarelli
Viktor E. Volchkov
Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
Viruses
Ebola
Marburg
Filovirus
polymerase
antiviral
inhibitors
author_facet Olivier Reynard
Xuan-Nhi Nguyen
Nathalie Alazard-Dany
Véronique Barateau
Andrea Cimarelli
Viktor E. Volchkov
author_sort Olivier Reynard
title Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_short Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_full Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_fullStr Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_full_unstemmed Identification of a New Ribonucleoside Inhibitor of Ebola Virus Replication
title_sort identification of a new ribonucleoside inhibitor of ebola virus replication
publisher MDPI AG
series Viruses
issn 1999-4915
publishDate 2015-12-01
description The current outbreak of Ebola virus (EBOV) in West Africa has claimed the lives of more than 15,000 people and highlights an urgent need for therapeutics capable of preventing virus replication. In this study we screened known nucleoside analogues for their ability to interfere with EBOV replication. Among them, the cytidine analogue β-d-N4-hydroxycytidine (NHC) demonstrated potent inhibitory activities against EBOV replication and spread at non-cytotoxic concentrations. Thus, NHC constitutes an interesting candidate for the development of a suitable drug treatment against EBOV.
topic Ebola
Marburg
Filovirus
polymerase
antiviral
inhibitors
url http://www.mdpi.com/1999-4915/7/12/2934
work_keys_str_mv AT olivierreynard identificationofanewribonucleosideinhibitorofebolavirusreplication
AT xuannhinguyen identificationofanewribonucleosideinhibitorofebolavirusreplication
AT nathaliealazarddany identificationofanewribonucleosideinhibitorofebolavirusreplication
AT veroniquebarateau identificationofanewribonucleosideinhibitorofebolavirusreplication
AT andreacimarelli identificationofanewribonucleosideinhibitorofebolavirusreplication
AT viktorevolchkov identificationofanewribonucleosideinhibitorofebolavirusreplication
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