A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells

A Novel Mechanism of 17-AAG Therapeutic Efficacy on HSP90 Inhibition in MYCN-Amplified Neuroblastoma Cells

BackgroundNeuroblastoma is the most common pediatric extra-cranial nervous system tumor, originating from neural crest elements and giving rise to tumors in the adrenal medulla and sympathetic chain ganglia. Amplification of MYCN confers increased malignancy and poorer prognosis in high-risk neurobl...

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Bibliographic Details
Main Authors: Reine Hanna, Jad Abdallah, Tamara Abou-Antoun
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Oncology
Subjects:
neuroblastoma
HSP90
17-AAG
IMR-32
SK-N-SH
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.624560/full

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