Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway

Saponins From Paris forrestii (Takht.) H. Li Display Potent Activity Against Acute Myeloid Leukemia by Suppressing the RNF6/AKT/mTOR Signaling Pathway

Saponins are amphipathic glycosides found in traditional Chinese medicines. In the present study, we isolated a panel of saponins from Paris forrestii (Takht.) H. Li, a unique plant found in Tibet and Yunnan provinces, China. By examining their activities in suppressing acute myeloid leukemia (AML)...

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Bibliographic Details
Main Authors: Qin Lu, Yuanming He, Yuehu Wang, Li Gao, Yunjing Zheng, Zubin Zhang, Biyin Cao, Qi Wang, Xinliang Mao, Shaoyan Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
TSPf
RNF6/AKT/mTOR signaling pathway
acute myeloid leukemia
herbal medicine
saponins
cell apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00673/full

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