Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients
Background: Impaired executive function (EF) is associated with a range of typical clinical characteristics and psychosocial dysfunction in major depressive disorder (MDD). However, because of the lack of objective cognitive tests, inconsistencies in research results, and improvement in patients...
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doaj-99d0dd82dc544f1ea53cd4247bf8169e2021-01-28T04:49:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-01-011110.3389/fpsyt.2020.538333538333Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD PatientsYuchen Wang0Yuchen Wang1Aixia Zhang2Chunxia Yang3Gaizhi Li4Ning Sun5Ning Sun6Penghong Liu7Yanfang Wang8Kerang Zhang9Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Medical Psychology, College of Humanities and Social Science, Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaCollege of Nursing, Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaDepartment of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, ChinaBackground: Impaired executive function (EF) is associated with a range of typical clinical characteristics and psychosocial dysfunction in major depressive disorder (MDD). However, because of the lack of objective cognitive tests, inconsistencies in research results, and improvement in patients' subjective experience, few clinicians are concerned with the persistent impairment of EF in euthymia. The study makes a further investigation for EF in remitted and partially remitted MDD patients via multiple EF tests and fMRI, so as to explore the executive function of patients in euthymia.Methods: We recruited 19 MDD patients and 17 age-, gender-, and education-matched healthy controls (HCs). All participants completed EF tests and fMRI scanning. Bilateral dorsolateral prefrontal cortex (dlPFC) regions were selected as the region of interests (ROIs) to conduct seed-based functional connectivity (FC). We conducted fractional amplitude of low-frequency fluctuations (fALFF) analysis for all ROIs and whole brain.Results: All MDD patients were in remission or partial remission, and they were comparable with HCs on all the EF tests. MDD group showed increased positive FC between left dlPFC and cerebellar Crus I, right dlPFC and supramarginal gyrus after 8-weeks treatment, even taking residual depressive symptoms into account. We did not find group difference of fALFF value.Conclusion: MDD patients persisted with EF impairment despite the remission or partially remission of depressive symptoms. Clinicians should focus on residual cognitive symptoms, which may contribute to maximize the efficacy of routine therapy.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.538333/fullmajor depressive disordersexecutive functionsfMRItherapypersistent cognition impairment |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yuchen Wang Yuchen Wang Aixia Zhang Chunxia Yang Gaizhi Li Ning Sun Ning Sun Penghong Liu Yanfang Wang Kerang Zhang |
spellingShingle |
Yuchen Wang Yuchen Wang Aixia Zhang Chunxia Yang Gaizhi Li Ning Sun Ning Sun Penghong Liu Yanfang Wang Kerang Zhang Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients Frontiers in Psychiatry major depressive disorders executive functions fMRI therapy persistent cognition impairment |
author_facet |
Yuchen Wang Yuchen Wang Aixia Zhang Chunxia Yang Gaizhi Li Ning Sun Ning Sun Penghong Liu Yanfang Wang Kerang Zhang |
author_sort |
Yuchen Wang |
title |
Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients |
title_short |
Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients |
title_full |
Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients |
title_fullStr |
Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients |
title_full_unstemmed |
Enhanced Functional Connectivity Within Executive Function Network in Remitted or Partially Remitted MDD Patients |
title_sort |
enhanced functional connectivity within executive function network in remitted or partially remitted mdd patients |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2021-01-01 |
description |
Background: Impaired executive function (EF) is associated with a range of typical clinical characteristics and psychosocial dysfunction in major depressive disorder (MDD). However, because of the lack of objective cognitive tests, inconsistencies in research results, and improvement in patients' subjective experience, few clinicians are concerned with the persistent impairment of EF in euthymia. The study makes a further investigation for EF in remitted and partially remitted MDD patients via multiple EF tests and fMRI, so as to explore the executive function of patients in euthymia.Methods: We recruited 19 MDD patients and 17 age-, gender-, and education-matched healthy controls (HCs). All participants completed EF tests and fMRI scanning. Bilateral dorsolateral prefrontal cortex (dlPFC) regions were selected as the region of interests (ROIs) to conduct seed-based functional connectivity (FC). We conducted fractional amplitude of low-frequency fluctuations (fALFF) analysis for all ROIs and whole brain.Results: All MDD patients were in remission or partial remission, and they were comparable with HCs on all the EF tests. MDD group showed increased positive FC between left dlPFC and cerebellar Crus I, right dlPFC and supramarginal gyrus after 8-weeks treatment, even taking residual depressive symptoms into account. We did not find group difference of fALFF value.Conclusion: MDD patients persisted with EF impairment despite the remission or partially remission of depressive symptoms. Clinicians should focus on residual cognitive symptoms, which may contribute to maximize the efficacy of routine therapy. |
topic |
major depressive disorders executive functions fMRI therapy persistent cognition impairment |
url |
https://www.frontiersin.org/articles/10.3389/fpsyt.2020.538333/full |
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