Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn

Carrageenan induced phosphorylation of Akt is dependent on neurokinin-1 expressing neurons in the superficial dorsal horn

<p>Abstract</p> <p>Background</p> <p>Paw carrageenan induces activation of phosphatidylinositol 3-kinase (PI-3K) and Akt in dorsal horn neurons in addition to induction of pain behavior. Spinal PI-3K activation is also thought to be required for inflammation-induced tra...

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Bibliographic Details
Main Authors: Choi Jeong IL, Koehrn Fred J, Sorkin Linda S
Format: Article
Language:English
Published: SAGE Publishing 2012-01-01
Series:Molecular Pain
Subjects:
spinal sensitization
receptor trafficking
PI-3K
inflammatory pain
AMPA
P-Akt
GluA1
NK1 receptor
Online Access:http://www.molecularpain.com/content/8/1/4

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