Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity
Due to improvements in chemotherapeutic agents, cancer treatment efficacy and cancer patient survival rates have greatly improved, but unfortunately gonadal damage remains a major complication. Gonadotoxic chemotherapy, including alkylating agents during reproductive age, can lead to iatrogenic prem...
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doaj-99d5344de25f40e2a1678d8ca755158f2020-11-25T03:44:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-01217792779210.3390/ijms21207792Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian ToxicityHyun-Woong Cho0Sanghoon Lee1Kyung-Jin Min2Jin Hwa Hong3Jae Yun Song4Jae Kwan Lee5Nak Woo Lee6Tak Kim7Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDepartment of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, KoreaDue to improvements in chemotherapeutic agents, cancer treatment efficacy and cancer patient survival rates have greatly improved, but unfortunately gonadal damage remains a major complication. Gonadotoxic chemotherapy, including alkylating agents during reproductive age, can lead to iatrogenic premature ovarian insufficiency (POI), and loss of fertility. In recent years, the demand for fertility preservation has increased dramatically among female cancer patients. Currently, embryo and oocyte cryopreservation are the only established options for fertility preservation in women. However, there is growing evidence for other experimental techniques including ovarian tissue cryopreservation, oocyte in vitro maturation, artificial ovaries, stem cell technologies, and ovarian suppression. To prevent fertility loss in women with cancer, individualized fertility preservation options including established and experimental techniques that take into consideration the patient’s age, marital status, chemotherapy regimen, and the possibility of treatment delay should be provided. In addition, effective multidisciplinary oncofertility strategies that involve a highly skilled and experienced oncofertility team consisting of medical oncologists, gynecologists, reproductive biologists, surgical oncologists, patient care coordinators, and research scientists are necessary to provide cancer patients with high-quality care.https://www.mdpi.com/1422-0067/21/20/7792gonadotoxicityfertility preservationembryo cryopreservationoocyte cryopreservationovarian tissue cryopreservationoocyte in vitro maturation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hyun-Woong Cho Sanghoon Lee Kyung-Jin Min Jin Hwa Hong Jae Yun Song Jae Kwan Lee Nak Woo Lee Tak Kim |
spellingShingle |
Hyun-Woong Cho Sanghoon Lee Kyung-Jin Min Jin Hwa Hong Jae Yun Song Jae Kwan Lee Nak Woo Lee Tak Kim Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity International Journal of Molecular Sciences gonadotoxicity fertility preservation embryo cryopreservation oocyte cryopreservation ovarian tissue cryopreservation oocyte in vitro maturation |
author_facet |
Hyun-Woong Cho Sanghoon Lee Kyung-Jin Min Jin Hwa Hong Jae Yun Song Jae Kwan Lee Nak Woo Lee Tak Kim |
author_sort |
Hyun-Woong Cho |
title |
Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity |
title_short |
Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity |
title_full |
Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity |
title_fullStr |
Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity |
title_full_unstemmed |
Advances in the Treatment and Prevention of Chemotherapy-Induced Ovarian Toxicity |
title_sort |
advances in the treatment and prevention of chemotherapy-induced ovarian toxicity |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-10-01 |
description |
Due to improvements in chemotherapeutic agents, cancer treatment efficacy and cancer patient survival rates have greatly improved, but unfortunately gonadal damage remains a major complication. Gonadotoxic chemotherapy, including alkylating agents during reproductive age, can lead to iatrogenic premature ovarian insufficiency (POI), and loss of fertility. In recent years, the demand for fertility preservation has increased dramatically among female cancer patients. Currently, embryo and oocyte cryopreservation are the only established options for fertility preservation in women. However, there is growing evidence for other experimental techniques including ovarian tissue cryopreservation, oocyte in vitro maturation, artificial ovaries, stem cell technologies, and ovarian suppression. To prevent fertility loss in women with cancer, individualized fertility preservation options including established and experimental techniques that take into consideration the patient’s age, marital status, chemotherapy regimen, and the possibility of treatment delay should be provided. In addition, effective multidisciplinary oncofertility strategies that involve a highly skilled and experienced oncofertility team consisting of medical oncologists, gynecologists, reproductive biologists, surgical oncologists, patient care coordinators, and research scientists are necessary to provide cancer patients with high-quality care. |
topic |
gonadotoxicity fertility preservation embryo cryopreservation oocyte cryopreservation ovarian tissue cryopreservation oocyte in vitro maturation |
url |
https://www.mdpi.com/1422-0067/21/20/7792 |
work_keys_str_mv |
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