Global and Local Persistence of Influenza A(H5N1) Virus
An understanding of the global migration dynamics of highly pathogenic avian influenza A(H5N1) virus is helpful for surveillance and disease prevention. To characterize the migration network of this virus, we used genetic analysis, which supported a global persistence model in which each of 9 region...
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doaj-99dc30892a374d76bf4d57f445e856d92020-11-25T00:31:04ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592014-08-012081287129510.3201/eid2008.130910Global and Local Persistence of Influenza A(H5N1) VirusXianbin LiZhong ZhangAilian YuSimon Y. W. HoMichael J. CarrWeimin ZhengYanzhou ZhangChaodong ZhuFumin LeiWeifeng ShiAn understanding of the global migration dynamics of highly pathogenic avian influenza A(H5N1) virus is helpful for surveillance and disease prevention. To characterize the migration network of this virus, we used genetic analysis, which supported a global persistence model in which each of 9 regions acts to some extent as a source. Siberia is the major hub for the dispersal of the virus. Southeast Asia and Africa are major sources of genetically and antigenically novel strains. We found evidence of local persistence of the virus in Southeast Asia and Africa, which is rare for human influenza A viruses. The differences in migration dynamics between avian and human influenza viruses might help with the design of region-specific surveillance efforts and the selection of vaccine candidates.https://wwwnc.cdc.gov/eid/article/20/8/13-0910_articleH5N1avian influenzamigration networkpersistencesourceinfluenza |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xianbin Li Zhong Zhang Ailian Yu Simon Y. W. Ho Michael J. Carr Weimin Zheng Yanzhou Zhang Chaodong Zhu Fumin Lei Weifeng Shi |
spellingShingle |
Xianbin Li Zhong Zhang Ailian Yu Simon Y. W. Ho Michael J. Carr Weimin Zheng Yanzhou Zhang Chaodong Zhu Fumin Lei Weifeng Shi Global and Local Persistence of Influenza A(H5N1) Virus Emerging Infectious Diseases H5N1 avian influenza migration network persistence source influenza |
author_facet |
Xianbin Li Zhong Zhang Ailian Yu Simon Y. W. Ho Michael J. Carr Weimin Zheng Yanzhou Zhang Chaodong Zhu Fumin Lei Weifeng Shi |
author_sort |
Xianbin Li |
title |
Global and Local Persistence of Influenza A(H5N1) Virus |
title_short |
Global and Local Persistence of Influenza A(H5N1) Virus |
title_full |
Global and Local Persistence of Influenza A(H5N1) Virus |
title_fullStr |
Global and Local Persistence of Influenza A(H5N1) Virus |
title_full_unstemmed |
Global and Local Persistence of Influenza A(H5N1) Virus |
title_sort |
global and local persistence of influenza a(h5n1) virus |
publisher |
Centers for Disease Control and Prevention |
series |
Emerging Infectious Diseases |
issn |
1080-6040 1080-6059 |
publishDate |
2014-08-01 |
description |
An understanding of the global migration dynamics of highly pathogenic avian influenza A(H5N1) virus is helpful for surveillance and disease prevention. To characterize the migration network of this virus, we used genetic analysis, which supported a global persistence model in which each of 9 regions acts to some extent as a source. Siberia is the major hub for the dispersal of the virus. Southeast Asia and Africa are major sources of genetically and antigenically novel strains. We found evidence of local persistence of the virus in Southeast Asia and Africa, which is rare for human influenza A viruses. The differences in migration dynamics between avian and human influenza viruses might help with the design of region-specific surveillance efforts and the selection of vaccine candidates. |
topic |
H5N1 avian influenza migration network persistence source influenza |
url |
https://wwwnc.cdc.gov/eid/article/20/8/13-0910_article |
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