Oncofertility in women cured of hodgkin’s lymphoma as a child

Oncofertility in women cured of hodgkin’s lymphoma as a child

The concept of risk-adapted therapy is a modern standard of choice for the treatment regimen of Hodgkin’s lymphoma in childhood.  As a rule, patients are distributed depending on the number of factors in the groups of low, intermediate and high risk with a  particular volume of the treatment program...

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Bibliographic Details
Main Authors: S. A. Kuleva, D. N. Kurochkina, D. A. Zvyagintseva, S. V. Ivanova, V. V. Tsyrlina
Format: Article
Language:Russian
Published: Remedium Group LLC 2019-04-01
Series:Медицинский совет
Subjects:
girls
women
hodgkin’s lymphoma
gonadotoxicity
fertility
alkylating drugs
radiation therapy
Online Access:https://www.med-sovet.pro/jour/article/view/2996
Description
Summary:The concept of risk-adapted therapy is a modern standard of choice for the treatment regimen of Hodgkin’s lymphoma in childhood.  As a rule, patients are distributed depending on the number of factors in the groups of low, intermediate and high risk with a  particular volume of the treatment program. The rational use of chemotherapy and radiation therapy can reduce the risk of gonadal  toxicity. Loss of oocytes in patients receiving Hodgkin’s lymphoma therapy in childhood is usually associated with systemic  chemotherapy and pelvic irradiation. A combination of inhibin B and FSH is proposed as a screening marker to assess the gonadotoxic  effects of chemotherapy, in both girls and boys.
ISSN:2079-701X
2658-5790

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